生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
liquid
分子量
18.1 kDa (162 aa, 264-402 aa + His tag)
包装
pkg of 100 μg
浓度
1 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... BMP8B(656)
一般描述
The BMP8B (bone morphogenetic protein 8b) gene is mapped to human chromosome 1p34.2. It is also expressed in testis germ cell.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-β (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
生化/生理作用
The BMP8B (bone morphogenetic protein 8b) gene expression prevents cancer cell proliferation and activates cell death. Decreased gene expression is observed in pancreatic cancer. BMP8B mediates the process of placentation, by regulating cell division, differentiation and survival. It prevents glucocorticoid-induced bone cell death.
外形
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Genetic variants in BMP8B gene are associated with growth traits in Chinese native cattle
Cao XK, et al.
Gene, 532(1), 115-120 (2013)
Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
Zhao GQ and Hogan BLM
Mechanisms of Development, 57(2), 159-168 (1996)
Andrew J Whittle et al.
Cell, 149(4), 871-885 (2012-05-15)
Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, here, we describe a role for BMP8B in the direct regulation of thermogenesis. BMP8B is induced
Developmental dysplasia of the hip: linkage mapping and whole exome sequencing identify a shared variant in CX3CR1 in all affected members of a large multigeneration family
Feldman GJ, et al.
Journal of Bone and Mineral Research, 28(12), 2540-2549 (2013)
Abdo Mahli et al.
Cells, 8(5) (2019-05-18)
Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome. The bone morphogenetic protein-8B (BMP8B) has been shown to be expressed in brown adipose tissues and the hypothalamus and to affect thermogenesis and susceptibility
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