T0410
Tiapride hydrochloride
别名:
N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H24N2O4S · HCl
化学文摘社编号:
分子量:
364.89
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
256-908-4
MDL number:
InChI key
OTFDPNXIVHBTKW-UHFFFAOYSA-N
InChI
1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H
SMILES string
Cl.CCN(CC)CCNC(=O)c1cc(ccc1OC)S(C)(=O)=O
storage temp.
2-8°C
Gene Information
human ... DRD2(1813), DRD3(1814)
Application
Tiapride and inhibitor of nitric oxide synthase were coadministered to mice to study the effect of dopamine D2 transmission in catalepsy.
Biochem/physiol Actions
Tiapride, an atypical neuroleptic agent, antagonizes D2 and D3 dopamine receptors. It exhibits anti-dyskinetic and anxiolytic activities. It is effective in the management of alcohol withdrawal and treatment of tic disease in children.
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Maria Cavas et al.
Progress in neuro-psychopharmacology & biological psychiatry, 26(1), 69-73 (2002-02-21)
This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 receptors, in male mice. Catalepsy was measured by the
M S Lidow et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 939-946 (1997-11-14)
The RNase Protection Assay was used to examine the regulation of D2 and D4 dopamine receptor mRNAs in the cerebral cortex and neostriatum of nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone
C Cohen et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 566-573 (1997-11-14)
The ability of tiapride, a selective D2/D3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required
C Eggers et al.
European archives of psychiatry and neurological sciences, 237(4), 223-229 (1988-01-01)
Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the
Transcortical motor aphasia and unilateral parkinsonism in a case of hyperostosis frontalis.
Stefan Brodoehl et al.
Neurology, 80(16), 1536-1537 (2013-04-17)
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