T0642
杀结核菌素
from Streptomyces tubercidicus, ~95%
别名:
7-Deazaadenosine
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关于此项目
经验公式（希尔记法）:
C11H14N4O4
化学文摘社编号:
分子量:
266.25
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-703-4
Beilstein/REAXYS Number:
38498
MDL number:
biological source
Streptomyces tubercidicus
Quality Segment
assay
~95%
form
powder
color
off-white
antibiotic activity spectrum
fungi, parasites, viruses
mode of action
DNA synthesis | interferes
SMILES string
O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
InChI
1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1
InChI key
HDZZVAMISRMYHH-KCGFPETGSA-N
Gene Information
rat ... Adora1(29290)
General description
Chemical structure: nucleoside
Application
Biochem/physiol Actions
Tubercidin is a toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. It inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata. Tubercidin inhibits glycolysis in Trypanosoma brucei. Tubercidin inhibits both chemotaxis and chemotaxis-dependent cell streaming of Dictyostelium, and chemotaxis of neutrophils at concentrations that have little effect on cell viability.
Toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. Mode of action: Inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
警示词
Danger
危险代码
预防性声明
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges