T0702
D-γ-Tocotrienol
from palm oil, ≥80% (GC)
别名:
(R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol
生物来源
palm oil
方案
≥80% (GC)
储存温度
−20°C
SMILES字符串
C/C(CC/C=C(C)/CCC=C(C)C)=C\CC[C@@]1(C)OC2=C(C)C(C)=C(O)C=C2CC1
InChI
1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1
InChI key
OTXNTMVVOOBZCV-WAZJVIJMSA-N
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生化/生理作用
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. In addition to its antioxidant properties γ-tocotrienol has been shown to inhibit the NF-κB activation pathway. γ-tocotrienol also acts as an inhibitor of HMG-CoA, the rate limiting enzyme in cholesterol biosynthesis.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Suzana Makpol et al.
Oxidative medicine and cellular longevity, 2012, 785743-785743 (2012-08-25)
In this study, we determined the molecular mechanism of γ-tocotrienol (GTT) in preventing cellular aging by focusing on its anti-apoptotic effect in stress-induced premature senescence (SIPS) model of human diploid fibroblasts (HDFs). Results obtained showed that SIPS exhibited senescent-phenotypic characteristic
Beatrycze Nowicka et al.
Biochimica et biophysica acta, 1828(2), 233-240 (2012-09-11)
Lipid peroxidation is an oxidation reaction leading to the generation of lipid hydroperoxides. Here we present comparative data on the inhibition of lipid peroxidation by a variety of biological prenyllipids in liposomes prepared from natural lipid membranes. Lipid peroxidation was
Tetsuro Matsunaga et al.
Molecular medicine reports, 5(4), 905-909 (2012-02-02)
Tocotrienols, members of the vitamin E family, have been shown to possess anti-inflammatory properties and display activity against a variety of chronic diseases, such as cancer, cardiovascular and neurological diseases. However, whether tocotrienols contribute to the prevention of inflammatory responses
Kanjoormana A Manu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(8), 2220-2229 (2012-02-22)
Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective. Hence, novel agents that are safe and effective are urgently needed. Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in
Bilal S Abuasal et al.
Lipids, 47(5), 461-469 (2012-01-25)
γ-Tocotrienol (γ-T3), a member of the vitamin E family, has been reported to possess an anticancer activity. γ-T3 is a lipophilic compound with low oral bioavailability. Previous studies showed that γ-T3 has low intestinal permeability. Thus, we have hypothesized that
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