T0702
D-γ-Tocotrienol
from palm oil, ≥80% (GC)
别名:
(R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol
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关于此项目
biological source
palm oil
assay
≥80% (GC)
storage temp.
−20°C
SMILES string
C/C(CC/C=C(C)/CCC=C(C)C)=C\CC[C@@]1(C)OC2=C(C)C(C)=C(O)C=C2CC1
InChI
1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1
InChI key
OTXNTMVVOOBZCV-WAZJVIJMSA-N
Biochem/physiol Actions
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. In addition to its antioxidant properties γ-tocotrienol has been shown to inhibit the NF-κB activation pathway. γ-tocotrienol also acts as an inhibitor of HMG-CoA, the rate limiting enzyme in cholesterol biosynthesis.
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shilpa S Kulkarni et al.
International immunopharmacology, 14(4), 495-503 (2012-09-25)
Gamma-tocotrienol (GT3), a promising radioprotectant, is shown to protect CD2F1 mice from radiation-induced neutropenia and thrombocytopenia when given 24h prior to total-body irradiation. GT3 also is shown to increase white blood cells (WBC) and absolute neutrophil counts (ANC) transiently in
Archana Gopalan et al.
Cancer letters, 328(2), 285-296 (2012-10-16)
Present study shows that drug resistant human breast cancer cells are enriched in cancer stem-like cells (CSCs) and express elevated levels of Stat-3 signaling mediators, which contribute to CSC enrichment. Simvastatin (SVA) and gamma-tocotrienol (γT3) eliminate enriched CSCs and suppress
Tetsuro Matsunaga et al.
Molecular medicine reports, 5(4), 905-909 (2012-02-02)
Tocotrienols, members of the vitamin E family, have been shown to possess anti-inflammatory properties and display activity against a variety of chronic diseases, such as cancer, cardiovascular and neurological diseases. However, whether tocotrienols contribute to the prevention of inflammatory responses