T102
MDL-72222
≥96% (HPLC), solid
别名:
3-Tropanyl-3,5-dichlorobenzoate
方案
≥96% (HPLC)
表单
solid
颜色
white
溶解性
0.1 M HCl: slightly soluble
DMSO: soluble
H2O: insoluble
基因信息
rat ... Htr3a(79246)
应用
MDL-72222 may be used in 5-HT receptor-mediated cell signaling studies.
生化/生理作用
MDL-72222 is specific for the peripheral neuronal 5-hydroxytryptamine receptors of mammals. It suppresses voluntary ethanol consumption that is mediated by the 5-HT3 receptor.
Selective 5HT3 serotonin receptor antagonist.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
F Fadda et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 26(2), 107-110 (1991-01-01)
The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL
Satoshi Hagiwara et al.
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Esa Meririnne et al.
Basic & clinical pharmacology & toxicology, 98(4), 346-350 (2006-04-21)
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Wen Liu et al.
Pharmacology, biochemistry, and behavior, 84(2), 370-377 (2006-07-11)
A previous study indicated that pretreatment with repeated daily injections of serotonin-3 (5-HT3) receptor antagonists subsequently reduced the effectiveness of the 5-HT3 antagonists to attenuate ethanol intake under 24-h free-choice conditions; one possibility to account for this is that the
Karim A Alkadhi et al.
Brain research, 1234, 25-31 (2008-08-23)
Long-term depression (LTD) is a use-dependent decrease in synaptic efficacy widely recognized as a form of synaptic plasticity related to cognitive function in the central nervous system. Such response has previously not been demonstrated in autonomic ganglia. In the isolated
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