T102
MDL-72222
≥96% (HPLC), solid
别名:
3-Tropanyl-3,5-dichlorobenzoate
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关于此项目
经验公式（希尔记法）:
C15H17Cl2NO2
化学文摘社编号:
分子量:
314.21
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥96% (HPLC)
form
solid
color
white
solubility
0.1 M HCl: slightly soluble, DMSO: soluble, H2O: insoluble
Gene Information
rat ... Htr3a(79246)
Application
MDL-72222 may be used in 5-HT receptor-mediated cell signaling studies.
Biochem/physiol Actions
MDL-72222 is specific for the peripheral neuronal 5-hydroxytryptamine receptors of mammals. It suppresses voluntary ethanol consumption that is mediated by the 5-HT3 receptor.
Selective 5HT3 serotonin receptor antagonist.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
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F Fadda et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 26(2), 107-110 (1991-01-01)
The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL
Wen Liu et al.
Pharmacology, biochemistry, and behavior, 84(2), 370-377 (2006-07-11)
A previous study indicated that pretreatment with repeated daily injections of serotonin-3 (5-HT3) receptor antagonists subsequently reduced the effectiveness of the 5-HT3 antagonists to attenuate ethanol intake under 24-h free-choice conditions; one possibility to account for this is that the
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