T1427
曲普利啶 盐酸盐
Sigma Reference Standard
别名:
(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H22N2 · HCl
化学文摘社编号:
分子量:
314.85
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
SMILES string
CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
InChI key
WYUYEJNGHIOFOC-NWBUNABESA-N
packaging
vial of 500 mg
solubility
H2O: moderately soluble, ethanol: moderately soluble, methanol: moderately soluble
Gene Information
human ... HRH1(3269)
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Application
Triprolidine hydrochloride has been used as a histamine H1 ligand to assess its affinity for [125I]-iodophenpropit binding sites. Furthermore, triprolidine has also been used to evaluate quantitative structure-retention relationships of antihistamine drugs chromatographed on α1-acid glycoprotein columns.
Biochem/physiol Actions
H1 histamine receptor antagonist.
Packaging
Supplied in amber screw-cap vials
Preparation Note
Triprolidine hydrochloride is moderately soluble in methanol, ethanol and water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
F P Jansen et al.
British journal of pharmacology, 113(2), 355-362 (1994-10-01)
1. The binding of the first selective radiolabelled histamine H3-receptor antagonist [125I]-iodophenpropit to rat cerebral cortex membranes was characterized. 2. [125I]-iodophenpropit, radiolabelled to a high specific activity of 1900 Ci mmol-1, saturably bound to a single class of sites with
R Kaliszan et al.
Journal of chromatography. A, 722(1-2), 25-32 (1996-01-26)
Quantitative relationships between the structure of antihistamine drugs (AHD) and their retention on an alpha 1-acid glycoprotein (AGP) HPLC column (QSRR) were studied in order to identify characteristic structural features of the binding site for AHD on AGP. The hydrophobicity
Adnan Manassra et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 991-993 (2009-12-04)
An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v)
Ashok K Shakya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(32), 4071-4078 (2009-11-21)
A highly efficient, selective and specific method for simultaneous quantitation of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap-tandem mass spectrometry coupled with electro spray ionization (LC-ESI-ion trap-tandem MS) has been validated and successfully applied to a clinical
Gianluigi Tanda et al.
Journal of neurochemistry, 106(1), 147-157 (2008-03-28)
The pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H(1) histamine antagonists which have behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-chlorpheniramine were compared with triprolidine, a potent
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