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关于此项目
经验公式(希尔记法):
C20H31NO · HCl
化学文摘社编号:
分子量:
337.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
SMILES string
Cl[H].OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3
InChI key
QDWJJTJNXAKQKD-UHFFFAOYSA-N
form
solid
color
white
solubility
methanol: soluble 50 mg/ml, clear to hazy, colorless, H2O: soluble
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Application
DL-三己基哌啶盐酸盐已被用于开发基于端柱电化学发光(ECL)的毛细管区带电泳。
Biochem/physiol Actions
已知DL-三己基哌啶盐酸盐(盐酸苯海索)起抗毒蕈碱剂和中枢性抗胆碱能作用。它可用于控制所有帕金森病类型的症状,例如特发性和脑后动脉硬化。盐酸苯海索对副交感神经系统起抑制作用。
毒蕈碱型乙酰胆碱受体拮抗剂
Preparation Note
DL-三己基哌啶盐酸盐可溶于水。它以50 mg/ml的浓度溶于甲醇中,可得到澄清至浑浊的无色溶液。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
T Hayakawa et al.
Clinical and experimental pharmacology & physiology, 26(5-6), 421-425 (1999-07-01)
1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats. 2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 micrograms) into the medial forebrain bundle at
H E Shannon et al.
The Journal of pharmacology and experimental therapeutics, 290(2), 901-907 (1999-07-20)
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in the rat. Rats were trained to avoid or escape an electric shock delivered to the feet in a discrete trial procedure.
Determination of benzhexol hydrochloride by capillary zone electrophoresis with an end-column electrochemiluminescence detection.
Yan, J., et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 76(1), 11-16 (2004)
Y Kimura et al.
Brain research, 834(1-2), 6-12 (1999-07-17)
An amnesic effect of anticholinergic drugs was previously described from several behavioral studies. We examined this effect induced by trihexyphenidyl and biperiden, clinically used in the parkinsonism and schizophrenic patients, by using passive avoidance tasks. Both of these drugs (0.1-10
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