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T173

硫代-L-瓜氨酸

Name: 硫代-<SC>L</SC>-瓜氨酸
Brand: SIGMA

synthetic, solid

别名:

(S)-2-氨基-5-(硫脲基)戊酸, N⁵-氨基硫酮基甲基-L-鸟氨酸

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关于此项目

经验公式（希尔记法）:

C₆H₁₃N₃O₂S

化学文摘社编号:

156719-37-8

分子量:

191.25

UNSPSC Code:

12352204

Beilstein/REAXYS Number:

6844478

MDL number:

MFCD00935993

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biological source

synthetic

form

solid

color

white

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

N[C@@H](CCCNC(N)=S)C(O)=O

InChI

1S/C6H13N3O2S/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1

InChI key

BKGWACHYAMTLAF-BYPYZUCNSA-N

Biochem/physiol Actions

神经元和内皮亚型一氧化氮合酶的强效选择性抑制剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline.

E S Furfine et al.

The Journal of biological chemistry, 269(43), 26677-26683 (1994-10-28)

Potent and selective inhibition of neuronal nitric oxide synthase (nNOS) compared to endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia (stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of

Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.

H M Abu-Soud et al.

The Journal of biological chemistry, 269(51), 32318-32326 (1994-12-23)

Heme iron reduction in the nitric-oxide synthases (NOSs) requires calmodulin binding and is associated with increased NO synthesis and NADPH oxidation (Abu-Soud, H. M., and Stuehr, D. J. (1993) Proc. Natl. Acad. Sci., U. S. A. 90, 10769-10772). Here, we

L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.

C Frey et al.

The Journal of biological chemistry, 269(42), 26083-26091 (1994-10-21)

Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (NO). The enzyme is inhibited by a variety of N omega-monosubstituted L-arginine analogs, and some of these compounds are useful in reversing pathologies associated with the overproduction

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