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Merck
CN

T1816

抗-肿瘤坏死因子-α 山羊抗

affinity isolated antibody, lyophilized powder

别名:

抗-TNF-α

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关于此项目

NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, Neutral, WB
Citations:
4
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biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

pig

technique(s)

immunohistochemistry: 15 μg/mL, indirect ELISA: 0.5-1.0 μg/mL, neutralization: suitable, western blot: 0.1-0.2 μg/mL

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

pig ... TNF(397086)

General description

Tumor Necrosis Factor-α (TNF-α) also refers as cachectin is a cytokine produced in response to immunological challenges such as bacteria (lipopolysaccharides), parasites, mitogens, viruses and other cytokines. It has essential roles in antitumor activity, inflammation, septic shock, immune modulation, anorexia, cachexia, hematopoiesis and viral replication. It also facilitates the growth of human fibroblasts, collagenase production as well as can activates polymorphonuclear neutrophils and osteoclasts. Anti-Tumor Necrosis Factor-α antibody can be used in neutralization and immunoblotting (working concentration-0.1-0.2 μg/ml) for detecting porcine TNF-α. Goat anti-Tumor Necrosis Factor-α antibody reacts specifically with recombinant porcine tumor necrosis factor α.

Immunogen

recombinant porcine TNF-α expressed in Escherichia coli.

Application

Anti-Tumor Necrosis Factor-α antibody can be used in immunohistochemistry and indirect ELISA.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant porcine TNF-α.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

10 - Combustible liquids

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容


J M Dayer et al.
The Journal of experimental medicine, 162(6), 2163-2168 (1985-12-01)
Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated
D R Bertolini et al.
Nature, 319(6053), 516-518 (1986-02-06)
When leukocytes are exposed to mitogens or antigens in vitro, they release bone-resorbing activity into the culture supernatants which can be detected by bioassay. Like many lymphocyte-monocyte products, this activity has been difficult to purify because of its low abundance
B J Sugarman et al.
Science (New York, N.Y.), 230(4728), 943-945 (1985-11-22)
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated. rTNF-alpha had cytostatic or cytolytic effects on only some tumor cell lines. When administered



全球贸易项目编号

货号GTIN
T1816-.1MG04061832717272