T2408
Tolazamide
别名:
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
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关于此项目
经验公式（希尔记法）:
C14H21N3O3S
化学文摘社编号:
分子量:
311.40
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
214-588-3
MDL number:
solubility
0.1 M NaOH: soluble 4.3 mg/ml, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 2.7 mg/ml, DMSO: soluble 32.5 mg/ml, acetone: soluble 50 mg/ml, clear, colorless to light yellow
SMILES string
Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2
InChI
1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChI key
OUDSBRTVNLOZBN-UHFFFAOYSA-N
Gene Information
human ... ALB(213), KCNJ1(3758)
Application
Tolazamide has been used as a KATP channel inhibitor to study changes in mean arterial blood pressure (MAP) in rat models of severe hemorrhagic shock2.
Biochem/physiol Actions
Stimulates pancreatic islet cells to secrete insulin; blocks ATP-sensitive K+ channels.
Preparation Note
Tolazamide is soluble in acetone at 50 mg/ml and yields a clear, colorless to light yellow solution. Furthermore, tolazamide is soluble in DMSO at 32.5 mg/ml, in 0.1 N NaOH at 4.3 mg/ml and in 45% (w/v)aqueous 2-hyroxypropyl-β-cyclodextrin at 2.7 mg/ml. It is insoluble in water.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
J H Karam et al.
Diabetes, 35(12), 1314-1320 (1986-12-01)
Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a
J D Lev et al.
Diabetes care, 10(6), 679-682 (1987-11-01)
We evaluated therapeutic usefulness of the second-generation sulfonylurea agents glyburide and glipizide in non-insulin-dependent diabetic patients who were secondary failures on chlorpropamide or tolazamide. Twenty patients were treated with glyburide, and 10 of them were subsequently treated with glipizide. Fasting
U M Kabadi et al.
Archives of internal medicine, 148(8), 1745-1749 (1988-08-01)
The influence of sulfonylurea drugs in enhancing the effect of endogenous insulin is well documented. Furthermore, combination therapy with sulfonylurea and insulin is effective in the treatment of type II diabetes mellitus. Therefore, to assess the efficacy of this type
G Severin
Journal of chromatography, 386, 57-63 (1987-01-16)
A method is described for the determination of N-nitrosohexamethyleneimine, a potential carcinogen, in tolazamide bulk drug and pharmaceutical dosage forms. The technique of trace enrichment high-performance liquid chromatography is employed to obtain accurate quantitation of the analyte at levels approaching
Lichenoid drug eruption from chlorpropamide and tolazamide.
C B Franz et al.
Journal of the American Academy of Dermatology, 22(1), 128-129 (1990-01-01)
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