T2452
Talsaclidine
≥98% (HPLC), oil
别名:
(R)-3-(2-propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014
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关于此项目
经验公式（希尔记法）:
C10H15NO
化学文摘社编号:
分子量:
165.23
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
oil
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
SMILES string
C#CCO[C@H]1CN2CC[C@H]1CC2
InChI
1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
InChI key
XVFJONKUSLSKSW-JTQLQIEISA-N
Biochem/physiol Actions
Talsaclidine aids in promoting the nonamyloidogenic α-secretase pathway in model systems. It is more effective in stimulating muscarinic M 1 receptors than M 2 and M 3 receptors. In anesthetized guinea pigs, talsaclidine has no bronchospastic effects, but it produces contracture in isolated tracheal muscle. Talsaclidine is considered a potential candidate for cholinergic replacement therapy.
Talsaclidine is a M1 selective muscarinic receptor agonist.
Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Packaged under argon
Preparation Note
在氩气下包装
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Wienrich et al.
Life sciences, 68(22-23), 2593-2600 (2001-06-08)
In functional pharmacological assays, talsaclidine has been described as a functionally preferential M1 agonist with full intrinsic activity, and less pronounced effects at M2- and M3 receptors. In accordance with this, cholinomimetic central activation measured in rabbits by EEG recordings
A Walland et al.
European journal of pharmacology, 330(2-3), 213-219 (1997-07-09)
The aim of the present investigation was to determine the reasons why the muscarinic receptor agonist talsaclidine (WAL 2014 FU, 1-azabicyclo[2.2.2] octane,3-(2-propynyloxy)-, (R)-,(E)-2-butenedioate) is devoid of bronchospastic effects in anaesthetized guinea pigs but causes contracture in isolated tracheal muscle from
C Hock et al.
Annals of the New York Academy of Sciences, 920, 285-291 (2001-02-24)
Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid beta-peptides (A beta). Thus, lowering A beta production is a central therapeutic target in AD and may be achieved by modulating such
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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