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经验公式(希尔记法):
C15H11I3NNaO4
化学文摘社编号:
分子量:
672.96
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥95% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥95% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
shipped in
ambient
storage temp.
−20°C
SMILES string
[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
InChI
1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
InChI key
SBXXSUDPJJJJLC-YDALLXLXSA-M
Gene Information
human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)
Application
3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells. The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.
Biochem/physiol Actions
3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.
Preparation Note
3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
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相关内容
Product Information Sheet
Ye-Seul Yoon et al.
Biomolecules & therapeutics, 29(1), 83-89 (2020-06-17)
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by presence of α-synuclein-positive inclusions in the cytoplasm of oligodendrocytes. These glial cytoplasmic inclusions (GCIs) are considered an integral part of the pathogenesis of MSA, leading to demyelination and neuronal demise.
S T Ding et al.
Journal of animal science, 78(4), 927-933 (2000-04-28)
The beta-adrenergic receptors (betaAR) on the surface of mammalian cells are desensitized when the cell is stimulated by betaAR agonists to eliminate excessive response by the cell. Investigations with adipocytes, primarily rodent-derived cells, indicate other hormones and substrates also can
R Bunevicius et al.
The New England journal of medicine, 340(6), 424-429 (1999-02-11)
Patients with hypothyroidism are usually treated with thyroxine (levothyroxine) only, although both thyroxine and triiodothyronine are secreted by the normal thyroid gland. Whether thyroid secretion of triiodothyronine is physiologically important is unknown. We compared the effects of thyroxine alone with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2752-100MG | 04061837343117 |
| T2752-500MG | 04061832821238 |
| T2752-1G | 04061837343124 |