T2803
7-Ethoxy-4-(trifluoromethyl)coumarin
≥98% (TLC), powder
别名:
Ethyl 4-(trifluoromethyl)umbelliferyl ether
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关于此项目
经验公式（希尔记法）:
C12H9F3O3
化学文摘社编号:
分子量:
258.19
Beilstein:
8555209
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
产品名称
7-Ethoxy-4-(trifluoromethyl)coumarin, ≥98% (TLC)
方案
≥98% (TLC)
表单
powder
溶解性
chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)
荧光
λex 333 nm; λem 415 nm in methanol
储存温度
−20°C
SMILES字符串
CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3
InChI key
OLHOIERZAZMHGK-UHFFFAOYSA-N
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特点和优势
7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P-450 catalyzed O-de-ethylation.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
J G DeLuca et al.
Biochemical pharmacology, 37(9), 1731-1739 (1988-05-01)
The microsomal O-deethylation of a novel coumarin analog, 7-ethoxy-4-trifluoromethylcoumarin (EFC), to a fluorescent product was characterized. Results indicate that this analog provides a rapid, convenient and highly sensitive means to assay cytochrome P-450-mediated metabolism. Like microsomal 7-ethoxycoumarin (7-EC) O-deethylation, EFC
Chitra Sridar et al.
The Journal of pharmacology and experimental therapeutics, 301(3), 945-952 (2002-05-23)
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The
Haoming Zhang et al.
The Journal of pharmacology and experimental therapeutics, 338(3), 803-809 (2011-06-11)
In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants (CYP2B6.4 to CYP2B6.9) was investigated in a reconstituted system to gain a better understanding of the effects of the mutations on
J Chun et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(8), 905-911 (2000-07-20)
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, was tested for its ability to inactivate cytochrome P450s (P450s) 2B1 and 2B6. PPP inactivated the 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats with a K(I) of 11 microM. The 7-ethoxy-4-(trifluoromethyl)coumarin
Shih-Feng Lan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)
In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different
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