T3149
Tocinoic acid
≥97% (HPLC)
别名:
[Ile3]-Pressinoic acid
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关于此项目
经验公式（希尔记法）:
C30H44N8O10S2
化学文摘社编号:
分子量:
740.85
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
InChI
1S/C30H44N8O10S2/c1-3-14(2)24-29(46)34-18(8-9-22(32)40)26(43)36-20(11-23(33)41)27(44)37-21(30(47)48)13-50-49-12-17(31)25(42)35-19(28(45)38-24)10-15-4-6-16(39)7-5-15/h4-7,14,17-21,24,39H,3,8-13,31H2,1-2H3,(H2,32,40)(H2,33,41)(H,34,46)(H,35,42)(H,36,43)(H,37,44)(H,38,45)(H,47,48)
SMILES string
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(O)=O
InChI key
ITRWUGOBSKHPTA-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
storage temp.
−20°C
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Application
Tocinoic acid is an oxytocin receptor antagonist and is used to study effects of oxytocin and 5-HT1A receptors on the prosocial effects of 3,4 methylenedioxymethamphetamine (MDMA; ecstasy). It can also be used as a test compound for studying whether the release of protein disulfide isomerase activity is stimulated by activated platelets or not.
Biochem/physiol Actions
Tocinoic acid contains the ring structure of oxytocin that inhibits the release of melanocyte-stimulating hormones (MSH) the rat pituitary in vitro.
Other Notes
N-terminal hexapeptide fragment of oxytocin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A V Sirotkin et al.
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 68(1), 112-115 (1982-01-01)
Administration of arginin-vasotocin, oxytocin and their fragments had no effect on corticosterone content in the blood plasma of 10-month chickens whereas in 20 and 30-day chickens arginin-vasotocin and its terminal fragment: amid of prolyl-arginil-glycil, considerably increased the corticosterone content. The
A P Da Costa et al.
Journal of neuroendocrinology, 8(3), 163-177 (1996-03-01)
Oxytocin (OT) release within the brain is thought to play a major role in inducing maternal behaviour in a number of mammalian species but little is known about the sites of release which are important in this respect. We have
C Fotsch et al.
Bioorganic & medicinal chemistry letters, 9(15), 2125-2130 (1999-08-28)
On-resin macrocyclization via an SNAr reaction is employed in the synthesis of tocinoic acid analogs. Specifically, an N-terminal nitrofluorobenzene is attacked by a nucleophilic C-terminal sidechain. The remaining nitro group can be reduced and acylated. NMR is used to compare
M A Lang et al.
The American journal of physiology, 251(1 Pt 2), R77-R81 (1986-07-01)
To characterize the V2 receptor (for antidiuretic hormone), we have studied the effect of a number of neurohypophysial hormone analogues on cyclic AMP (cAMP) accumulation and short-circuit current in cultured epithelia formed by A6 cells. A6 is the designation of
P L Yeo et al.
Analytical chemistry, 65(21), 3061-3066 (1993-11-01)
Methodology is described for characterization of the kinetics and equilibria of thiol/disulfide interchange reactions of the disulfide bonds in the neurohypophyseal peptide hormones arginine vasopressin and oxytocin and the related peptides pressinoic acid and tocinoic acid. Thiol/disulfide interchange reaction mixtures
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