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Merck
CN

T3327

Sigma-Aldrich

Tubulysin A

≥95% (HPLC), from Streptomyces sp., film

别名:

TubA

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关于此项目

经验公式（希尔记法）:
C43H65N5O10S
化学文摘社编号:
205304-86-5
分子量:
844.07
MDL编号:
MFCD12912448
UNSPSC代码:
12352202
PubChem化学物质编号:
329826749

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生物来源

Streptomyces sp.

质量水平

100

方案

≥95% (HPLC)

表单

film

颜色

colorless to white

溶解性

organic solvents: soluble

运输

wet ice

储存温度

2-8°C

SMILES字符串

CC[C@H](C)[C@H](NC(=O)[C@H]1CCCCN1C)C(=O)N(COC(=O)CC(C)C)[C@H](C[C@@H](OC(C)=O)c2nc(cs2)C(=O)N[C@H](C[C@H](C)C(O)=O)Cc3ccc(O)cc3)C(C)C

InChI

1S/C43H65N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,23,25-28,31,34-36,38,50H,10-13,18-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28-,31+,34+,35+,36+,38-/m0/s1

InChI key

IBEDDHUHZBDXGB-OEJISELMSA-N

生化/生理作用

Tubulysin A is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays1.
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

制备说明

Tubulysin A is soluble in organic solvents.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
111M4726V
018K4710

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Gurmeet Kaur et al.
The Biochemical journal, 396(2), 235-242 (2006-02-24)
Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study.
Lindsay M Steirer et al.
PloS one, 6(11), e27249-e27249 (2011-11-19)
Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently, we showed that two human pathogens expressed a derivative of PSA containing
Christina M Van Itallie et al.
Molecular biology of the cell, 26(15), 2769-2787 (2015-06-13)
Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming proteins and actin. Here we identify a novel functional complex of the junction

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