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T3652

Sigma-Aldrich

雷公藤内酯

from Tripterygium wilfordii, ≥98% (HPLC), solid

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别名:
PG 490
经验公式（希尔记法）:
C20H24O6
CAS号:
38748-32-2
分子量:
360.40
MDL编号:
MFCD00210565
PubChem化学物质编号:
24900156
NACRES:
NA.77

生物来源

Tripterygium wilfordii

检测方案

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

DMSO: soluble

储存温度

2-8°C

SMILES字符串

O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-KTGKZQHOSA-N

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应用

雷公藤内酯已被用作NF-κB抑制剂，可用于研究人甲状腺癌细胞中细胞侵袭和血管生成的抑制6。雷公藤内酯也被用于研究其在间变性甲状腺癌细胞中的凋亡作用7。

生化/生理作用

雷公藤内酯是一种二萜三环氧化物，是中草药雷公藤（Tripterygium wilfordii） （TwHF）提取物中的主要活性成分 。它是一种有效的免疫抑制剂和抗炎药。雷公藤内酯已被证明在嘌呤盒/核因子和NF-κB介导的转录激活水平上抑制活化T细胞中IL-2的表达。它与环孢菌素A协同可促进动物模型中的移植物的存活，和抑制同种异体骨髓移植中的移植物抗宿主病。此外，它可诱导肿瘤细胞凋亡，并可部分通过抑制c-IAP2和c-IAP1，来增强肿瘤坏死因子（TNFα）诱导的细胞凋亡。

制备说明

雷公藤内酯可溶于DMSO中。储存溶液应在溶解后于-20℃保存在DMSO中。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Ruidong Li et al.
Oncology reports, 37(1), 442-448 (2016-11-24)
Cellular senescence, an irreversible growth arrest of cells, is involved in protection against cancer. Triptolide (TPL) plays an important role in immunosuppressive, anti-fertility, anti-cystogenesis and anticancer activities. However, effect and mechanism of TPL on cellular senescence-associated antitumor is rarely reported.
Xiang Wang et al.
Toxicology and applied pharmacology, 310, 32-40 (2016-08-25)
Triptolide (TP), derived from the medicinal plant Triterygium wilfordii Hook. f. (TWHF), is a diterpene triepoxide with variety biological and pharmacological activities. However, TP has been restricted in clinical application due to its narrow therapeutic window especially in reproductive system.
Chundong Song et al.
BMC complementary and alternative medicine, 19(1), 198-198 (2019-08-04)
Endothelial cell inflammation is a central event in the pathogenesis of numerous cardiovascular diseases, including sepsis and atherosclerosis. Triptolide, a principal bioactive ingredient of Traditional Chinese Medicine Tripterygium wilfordii Hook.F., displays anti-inflammatory actions in vivo. However, the mechanisms underlying these
Stefano Giustino Manzo et al.
Cancer research, 72(20), 5363-5373 (2012-08-29)
Triptolide is a bioactive ingredient in traditional Chinese medicine that exhibits diverse biologic properties, including anticancer properties. Among its many putative targets, this compound has been reported to bind to XPB, the largest subunit of general transcription factor TFIIH, and
Yang Huang et al.
Spine, 44(12), E707-E714 (2019-06-01)
The effect of triptolide on spinal cord injury (SCI) and inflammatory response was observed by establishing SCI rat model. And in vitro experiments were conducted to determine the underlying mechanism of triptolide-mediated in murine microglial cell line BV2. To determine
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