登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式(希尔记法):
C16H14N2O2
化学文摘社编号:
分子量:
266.29
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
SMILES string
COc1cc2ncc(nc2cc1OC)-c3ccccc3
InChI key
QNOXYUNHIGOWNY-UHFFFAOYSA-N
assay
≥98%
form
powder
solubility
methylene chloride: soluble 10 mg/mL, DMSO: soluble
storage temp.
2-8°C
Biochem/physiol Actions
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein.
Studies have reported that phosphorylation of tyrosine 857 in PDGF β-receptor is the most susceptible to inhibition by tyrphostin AG 12962.
Preparation Note
Tyrphostin AG 1296 is soluble in methylene chloride at 10 mg/ml and is also soluble in DMSO.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Nathan G Dolloff et al.
Cancer research, 67(2), 555-562 (2007-01-20)
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate cancer cells that metastasize to the skeleton respond to human bone marrow with a robust stimulation of the phosphatidylinositol 3-kinase/Akt pathway
Susanne Dell et al.
Investigative ophthalmology & visual science, 47(5), 1928-1937 (2006-04-28)
Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization. This study was undertaken to elucidate the mechanisms by which PDGF exerts its effects on corneal angiogenesis. Corneal neovascularization was induced
Saher Hamed et al.
PloS one, 5(11), e13986-e13986 (2010-11-19)
Autologous transplanted fat has a high resorption rate, providing a clinical challenge for the means to reduce it. Erythropoietin (EPO) has non-hematopoietic targets, and we hypothesized that EPO may improve long-term fat graft survival because it has both pro-angiogenic and
Ruei-Zeng Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10137-10142 (2014-07-02)
Endothelial colony-forming cells (ECFCs) are endothelial precursors that circulate in peripheral blood. Studies have demonstrated that human ECFCs have robust vasculogenic properties. However, whether ECFCs can exert trophic functions in support of specific stem cells in vivo remains largely unknown.
Kate Chao-Wei Chen et al.
Molecular vision, 13, 374-387 (2007-03-30)
The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading to ROS production and subsequent cell proliferation is not clear. We investigated the upstream membrane-bound target proteins involved in PDGF-stimulated
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持