T4192
Tyrphostin SU 1498
≥98%
别名:
(E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
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关于此项目
经验公式（希尔记法）:
C25H30N2O2
化学文摘社编号:
分子量:
390.52
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98%
form
solid
potency
700 nM IC50
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
InChI
1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChI key
JANPYFTYAGTSIN-FYJGNVAPSA-N
Application
Tyrphostin SU 1498 has been used as a VEGF inhibitor in mice1.
Biochem/physiol Actions
Potent and selective inhibitor of the VEGF receptor kinase, Flk-1. Very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase.
Preparation Note
Tyrphostin SU 1498 is soluble in DMSO.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Xiaorui Shi
The American journal of pathology, 174(5), 1692-1704 (2009-04-08)
This study explored the effect of acoustic trauma on cochlear pericytes. Transmission electron microscopy revealed that pericytes on capillaries of the stria vascularis were closely associated with the endothelium in both control guinea pigs and mice. Pericyte foot processes were
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