T4446
N-乙酰-L-酪氨酸
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线性分子式:
4-(HO)C6H4CH2CH(NHCOCH3)CO2H
化学文摘社编号:
分子量:
223.23
EC Number:
208-671-3
UNSPSC Code:
12352209
NACRES:
NA.26
Beilstein/REAXYS Number:
2697172
MDL number:
InChI
1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1
InChI key
CAHKINHBCWCHCF-JTQLQIEISA-N
SMILES string
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
biological source
non-animal source
assay
≥98.5%
form
crystalline powder
manufacturer/tradename
Ajinomoto
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, heavy metals, tested
solubility
H2O: 25 mg/mL
application(s)
pharmaceutical (small molecule)
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General description
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Application
L-Tyrosine is a non-essential amino acid. It can be used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. N-Acetyl-L-tyrosine is an acetylated derivative of the essential amino acid L-tyrosine with reported improved nutritional properties.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Investigation of DNA-protein cross-link formation between lysozyme and oxanine by mass spectrometry.
Hauh-Jyun Candy Chen et al.
Chembiochem : a European journal of chemical biology, 9(7), 1074-1081 (2008-03-21)
Reactive nitrogen species are implicated in inflammatory diseases and cancers. Oxanine (Oxa) is a DNA lesion product originating from the guanine base through exposure to nitric oxide, nitrous acid, or N-nitrosoindoles. Oxanine was found to mediate formation of DNA-protein cross-links
David I Pattison et al.
Biochemistry, 45(26), 8152-8162 (2006-06-28)
Hypochlorous acid (HOCl) is a powerful oxidant generated from H(2)O(2) and Cl(-) by the heme enzyme myeloperoxidase, which is released from activated leukocytes. HOCl possesses potent antibacterial properties, but excessive production can lead to host tissue damage that is implicated
T Nishiyama et al.
Journal of biochemistry, 127(3), 427-433 (2000-03-25)
It was previously revealed [Yamaguchi, H., Nishiyama, T., and Uchida, M. (1999) J. Biochem. 126, 261-265] that N-glycans of both the high-mannose and complex types have binding affinity for aromatic amino acid residues. This study shows that free N-glycans protect
A Rescigno et al.
Biochimica et biophysica acta, 1384(2), 268-276 (1998-07-11)
Tyrosinase is a copper containing protein which catalyzes the hydroxylation of monophenols and the oxidation of diphenols to o-quinones. The monophenolase activity of tyrosinase is characterized by a typical lag time. In this paper the influence of 3-hydroxyanthranilic acid on
Michael J Napolitano et al.
Chemical research in toxicology, 18(3), 501-508 (2005-03-22)
The reactions of aqueous ClO2 with tyrosine, N-acetyltyrosine, and dopa (3,4-dihydroxyphenylalanine) are investigated from pH 4 to 7. The reaction rates increase greatly with pH to give a series of oxidized products. Tyrosine and N-acetyltyrosine have similar reactivities with second-order
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