方案
≥99%
效能
5 μM IC 50: A1
9.3 μM IC50 (VEGF)
颜色
pale yellow
储存温度
2-8°C
SMILES字符串
Cc1cc2ncc(nc2cc1C)-c3ccc(O)c(O)c3
InChI
1S/C16H14N2O2/c1-9-5-12-13(6-10(9)2)18-14(8-17-12)11-3-4-15(19)16(20)7-11/h3-8,19-20H,1-2H3
InChI key
SMKFYHOKXJUJOT-UHFFFAOYSA-N
应用
Tyrphostin AG 1433 has been used for studying spermidine-induced auto-activation2.
生化/生理作用
PDGFβ receptor tyrosine kinase inhibitor.
法规信息
新产品
此项目有
Eisaku Yamamoto et al.
Bioscience, biotechnology, and biochemistry, 75(10), 2070-2072 (2011-10-08)
Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated
J Kroll et al.
The Journal of biological chemistry, 272(51), 32521-32527 (1998-01-24)
Vascular endothelial growth factor A (here referred to as VEGF) is an endothelium-specific growth factor that binds to two distinct receptor tyrosine kinases, designated Flt-1 and KDR/Flk-1. VEGF stimulates autophosphorylation of both receptors, but little is known about their signal
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