T5819
TRAIL Receptor 2/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
别名:
DR5, MK, TRICK2
重组
expressed in baculovirus infected Sf21 cells
方案
>95% (SDS-PAGE)
表单
lyophilized powder
分子量
~49 kDa by SDS-PAGE (reducing)
calculated mol wt ~40 kDa
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Tnfrsf10b(21933)
应用
TRAIL Receptor 2/Fc Chimera from mouse was used to study apoptosis induced by acetyl-keto-beta-boswellic acid isolated from Boswellia carterri and Boswellia serrata in prostate cancer cells via death receptor 5-mediated pathway.
生化/生理作用
Member of the TNFR superfamily that binds TRAIL and induces apoptosis in a variety of cell types.
Member of the TNFR superfamily that binds TRAIL and induces apoptosis in a variety of cell types. The degree of homology between the death domains of mouse TRAIL R2 and either human TRAIL R1 or TRAIL R2 is 76% and 79%, respectively.
TRAIL Receptor 2 also refers as DR5 or TRICK2 belongs to TNF receptor family and can induce apoptosis via FADD and caspase-8. It also promotes NF-κ-B activation.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
Inhibits apoptosis of mouse L929 cells treated with 20 ng/ml recombinant human TRAIL or 12 ng/ml cross-linked recombinant human TRAIL.
其他说明
Extracellular domain of mouse TRAIL R2 (a.a. 1-177) fused to the C-terminal Fc region of human IgG1.
法规信息
新产品
此项目有
Min Lu et al.
Cancer research, 68(4), 1180-1186 (2008-02-19)
Acetyl-keto-beta-boswellic acid (AKBA), a triterpenoid isolated from Boswellia carterri Birdw and Boswellia serrata, has been found to inhibit tumor cell growth and to induce apoptosis. The apoptotic effects and the mechanisms of action of AKBA were studied in LNCaP and
P Schneider et al.
Immunity, 7(6), 831-836 (1998-01-16)
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持