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Merck
CN

T5897

Sigma-Aldrich

Tuftsin acetate salt hydrate

≥97% (HPLC)

别名:

Thr-Lys-Pro-Arg

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关于此项目

经验公式（希尔记法）:
C21H40N8O6 · xC2H4O2 · yH2O
分子量:
500.59 (anhydrous free base basis)
MDL编号:
MFCD11045984
UNSPSC代码:
12352200
PubChem化学物质编号:
329826834

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方案

≥97% (HPLC)

表单

powder

颜色

white to off-white

储存温度

−20°C

SMILES字符串

O.CC(O)=O.C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C21H40N8O6.C2H4O2.H2O/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;1-2(3)4;/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);1H3,(H,3,4);1H2/t12-,13+,14+,15+,16+;;/m1../s1

InChI key

SMSBUFILHWPAMV-DZOCJTNESA-N

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储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBJ6030V
SLBJ1141V
SLBG3847V
SLBF0486V
SLBD5436V

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Jianghua Feng et al.
Contrast media & molecular imaging, 5(4), 223-230 (2010-08-28)
Fluorescein- and terbium-labelled tuftsin (Thr-Lys-Pro-Arg) and pentapeptide (Thr-Lys-Pro-Pro-Arg) were synthesized and their properties were evaluated in vitro by luminescence spectrometry and confocal microscopy as fluorescence probes to target macrophage cells in biological systems. An increase in fluorescence of macrophages incubated
Kata Horváti et al.
Journal of peptide science : an official publication of the European Peptide Society, 15(5), 385-391 (2009-03-26)
Tuberculosis (TB) is a bacterial infectious disease caused by Mycobacterium tuberculosis, a slow-growing, powerful human pathogen which can survive in the host macrophages. In the chemotherapy of such intracellular pathogens it is necessary to achieve relatively high level of the
Michael F Tweedle
Accounts of chemical research, 42(7), 958-968 (2009-06-26)
Radiotherapeutic drugs and medical imaging agents, although used for different purposes, both benefit from precise targeting. When systemically administered, either would be most useful if designed to find and bind only a tumor, single type of cell, or unique molecular
The chemical synthesis of the phagocytosis-stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties.
K Nishioka et al.
Biochimica et biophysica acta, 310(1), 230-237 (1973-05-17)
Magdalena Kukowska-Kaszuba et al.
Journal of medicinal chemistry, 54(7), 2447-2454 (2011-03-24)
New tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the

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