T5897
Tuftsin acetate salt hydrate
≥97% (HPLC)
别名:
Thr-Lys-Pro-Arg
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经验公式（希尔记法）:
C21H40N8O6 · xC2H4O2 · yH2O
分子量:
500.59 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C21H40N8O6.C2H4O2.H2O/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;1-2(3)4;/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);1H3,(H,3,4);1H2/t12-,13+,14+,15+,16+;;/m1../s1
SMILES string
O.CC(O)=O.C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
InChI key
SMSBUFILHWPAMV-DZOCJTNESA-N
assay
≥97% (HPLC)
form
powder
color
white to off-white
storage temp.
−20°C
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Kata Horváti et al.
Journal of peptide science : an official publication of the European Peptide Society, 15(5), 385-391 (2009-03-26)
Tuberculosis (TB) is a bacterial infectious disease caused by Mycobacterium tuberculosis, a slow-growing, powerful human pathogen which can survive in the host macrophages. In the chemotherapy of such intracellular pathogens it is necessary to achieve relatively high level of the
Michael F Tweedle
Accounts of chemical research, 42(7), 958-968 (2009-06-26)
Radiotherapeutic drugs and medical imaging agents, although used for different purposes, both benefit from precise targeting. When systemically administered, either would be most useful if designed to find and bind only a tumor, single type of cell, or unique molecular
Tuftsin derivatives of FITC, Tb-DOTA or Gd-DOTA as potential macrophage-specific imaging biomarkers.
Jianghua Feng et al.
Contrast media & molecular imaging, 5(4), 223-230 (2010-08-28)
Fluorescein- and terbium-labelled tuftsin (Thr-Lys-Pro-Arg) and pentapeptide (Thr-Lys-Pro-Pro-Arg) were synthesized and their properties were evaluated in vitro by luminescence spectrometry and confocal microscopy as fluorescence probes to target macrophage cells in biological systems. An increase in fluorescence of macrophages incubated
Magdalena Kukowska-Kaszuba et al.
Journal of medicinal chemistry, 54(7), 2447-2454 (2011-03-24)
New tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the
The chemical synthesis of the phagocytosis-stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties.
K Nishioka et al.
Biochimica et biophysica acta, 310(1), 230-237 (1973-05-17)
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