T6638
托萘酯
别名:
甲基-(3-间甲苯基)硫代氨基甲酸-2-萘酯
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关于此项目
经验公式（希尔记法）:
C19H17NOS
化学文摘社编号:
分子量:
307.41
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51302004
EC Number:
219-266-6
MDL number:
InChI key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI
1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
SMILES string
CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
chloroform: soluble 50 mg/mL
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
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Application
甲苯磺酸盐用于研究角鲨烯环氧酶抑制的限速步骤中，麦角甾醇（甾醇）的生物合成机理。 甲苯磺酸盐在临床上用于治疗皮肤感染，例如脚癣、股癣和癣菌。它也被用作抗真菌功效研究的比较化合物。
Biochem/physiol Actions
甲苯磺酸盐通过抑制角鲨烯环氧酶来防止麦角固醇生物合成。也有报道称其会扭曲菌丝并阻碍易感生物体中的菌丝生长。甲苯磺酸盐可抑制黄曲霉毒素的生物合成。
Packaging
1G,5G
Other Notes
保存于密闭容器内，置于干燥通风处。
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
T Ohmi et al.
Arzneimittel-Forschung, 41(8), 847-851 (1991-08-01)
In vitro and in vivo antifungal activities of the new imidazole derivative latoconazole ((+-)-(E)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-1- imidazolylacetonitrile, NND-318; CAS 101530-10-3) were studied in comparison with three major topical agents, clotrimazole, bifonazole and tolnaftate. The in vitro activity of latoconazole against dermatophytes was
Toma Kezutyte et al.
Acta poloniae pharmaceutica, 67(4), 327-334 (2010-07-20)
Abstract: Tolnaftate, an antifungal of thiocarbamate class, is used topically in 1% formulations. Its penetration into skin layers is a prerequisite for tolnaftate action against dermatophytes. The aim of this work was to optimize and validate a simple, rapid, accurate
Y Kobayashi et al.
Chemical & pharmaceutical bulletin, 46(11), 1797-1802 (1998-12-10)
The enhancing effects of various vehicles on the in vitro permeation of a hydrophilic model drug, 5-fluorouracil (5-FU), or a lipophilic model drug, tolnaftate (TN), through human nail plates were investigated using a modified side-by-side diffusion cell. Tip pieces from
Toma Kezutyte et al.
Acta poloniae pharmaceutica, 68(6), 965-973 (2011-12-01)
Five fatty acids (oleic, linoleic, myristic, lauric and capric) were incorporated in 10% (w/w) into ointment formulation and their influence on lipophilic model drug tolnaftate release in vitro and enhancing effect on tolnaftate penetration into epidermis and dermis of human
A K Dash et al.
Journal of pharmaceutical sciences, 91(4), 983-990 (2002-04-12)
Ethylcellulose microspheres containing tolnaftate (I) were prepared by the emulsion-solvent evaporation technique. An X-ray powder diffractometric method was developed to quantify the content of crystalline I in these microspheres. X-ray lines of I with d-spacings of 5.5 and 4.2 A
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