form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
chloroform: soluble 50 mg/mL
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
InChI
1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
InChI key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
Application
甲苯磺酸盐用于研究角鲨烯环氧酶抑制的限速步骤中，麦角甾醇（甾醇）的生物合成机理。 甲苯磺酸盐在临床上用于治疗皮肤感染，例如脚癣、股癣和癣菌。它也被用作抗真菌功效研究的比较化合物。
Biochem/physiol Actions
甲苯磺酸盐通过抑制角鲨烯环氧酶来防止麦角固醇生物合成。也有报道称其会扭曲菌丝并阻碍易感生物体中的菌丝生长。甲苯磺酸盐可抑制黄曲霉毒素的生物合成。
Packaging
1G,5G
Other Notes
保存于密闭容器内，置于干燥通风处。
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存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
相关内容
Product Information Sheet
A K Dash et al.
Journal of pharmaceutical sciences, 91(4), 983-990 (2002-04-12)
Ethylcellulose microspheres containing tolnaftate (I) were prepared by the emulsion-solvent evaporation technique. An X-ray powder diffractometric method was developed to quantify the content of crystalline I in these microspheres. X-ray lines of I with d-spacings of 5.5 and 4.2 A
Toma Kezutyte et al.
Acta poloniae pharmaceutica, 67(4), 327-334 (2010-07-20)
Abstract: Tolnaftate, an antifungal of thiocarbamate class, is used topically in 1% formulations. Its penetration into skin layers is a prerequisite for tolnaftate action against dermatophytes. The aim of this work was to optimize and validate a simple, rapid, accurate
Y Kobayashi et al.
Chemical & pharmaceutical bulletin, 46(11), 1797-1802 (1998-12-10)
The enhancing effects of various vehicles on the in vitro permeation of a hydrophilic model drug, 5-fluorouracil (5-FU), or a lipophilic model drug, tolnaftate (TN), through human nail plates were investigated using a modified side-by-side diffusion cell. Tip pieces from
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T6638-1G | 04061837371790 |
| T6638-5G | 04061837371806 |