T6638
托萘酯
别名:
甲基-(3-间甲苯基)硫代氨基甲酸-2-萘酯
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关于此项目
经验公式（希尔记法）:
C19H17NOS
化学文摘社编号:
分子量:
307.41
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51302004
EC Number:
219-266-6
MDL number:
InChI key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI
1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
SMILES string
CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
chloroform: soluble 50 mg/mL
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
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Application
甲苯磺酸盐用于研究角鲨烯环氧酶抑制的限速步骤中，麦角甾醇（甾醇）的生物合成机理。 甲苯磺酸盐在临床上用于治疗皮肤感染，例如脚癣、股癣和癣菌。它也被用作抗真菌功效研究的比较化合物。
Biochem/physiol Actions
甲苯磺酸盐通过抑制角鲨烯环氧酶来防止麦角固醇生物合成。也有报道称其会扭曲菌丝并阻碍易感生物体中的菌丝生长。甲苯磺酸盐可抑制黄曲霉毒素的生物合成。
Packaging
1G,5G
Other Notes
保存于密闭容器内，置于干燥通风处。
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
H Vanden Bossche et al.
Journal of veterinary pharmacology and therapeutics, 26(1), 5-29 (2003-02-27)
A limited number of antifungal agents is licensed for use in animals, however, many of those available for the treatment of mycoses in humans are used by veterinary practitioners. This review includes chemical aspects, spectra of activity, mechanisms of action
J Pannu et al.
Antimicrobial agents and chemotherapy, 53(8), 3273-3279 (2009-05-13)
NB-002 is an oil-in-water emulsion designed for use for the treatment of skin, hair, and nail infections. The activity of NB-002 was compared to the activities of the available antifungal drugs against the major dermatophytes responsible for cutaneous infections, Trichophyton
Andrew E Czeizel et al.
Reproductive toxicology (Elmsford, N.Y.), 18(3), 443-444 (2004-04-15)
Teratogenic studies of tolnaftate, an antifungal agent, in humans have not been published. The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996 contained 22843 fetuses or newborns with congenital abnormalities and 38151 matched controls without congenital
D Arul Dhas et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 993-1003 (2011-05-14)
Vibrational analysis of the thionocarbamate fungicide tolnaftate which is antidermatophytic, antitrichophytic and antimycotic agent, primarily inhibits the ergosterol biosynthesis in the fungus, was carried out using NIR FT-Raman and FTIR spectroscopic techniques. The equilibrium geometry, various bonding features, harmonic vibrational
S T Patil et al.
Fresenius' journal of analytical chemistry, 367(1), 91-93 (2001-03-03)
Tolnaftate, an antifungal drug (TF) and related impurities arising from synthesis, viz., N-methyl-m-toluidine (NMmT) and beta-naphthol-1-chlorothio carbamate (beta-NCTC) can be determined by supercritical fluid chromatography. Even though it was possible to elute TF completely with neat SCF CO2, the peaks
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