表单
powder
储存条件
(Keep container tightly closed in a dry and well-ventilated place.)
颜色
white to off-white
溶解性
chloroform: soluble 50 mg/mL
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
InChI
1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
InChI key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
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应用
甲苯磺酸盐用于研究角鲨烯环氧酶抑制的限速步骤中，麦角甾醇（甾醇）的生物合成机理。 甲苯磺酸盐在临床上用于治疗皮肤感染，例如脚癣、股癣和癣菌。它也被用作抗真菌功效研究的比较化合物。
生化/生理作用
甲苯磺酸盐通过抑制角鲨烯环氧酶来防止麦角固醇生物合成。也有报道称其会扭曲菌丝并阻碍易感生物体中的菌丝生长。甲苯磺酸盐可抑制黄曲霉毒素的生物合成。
包装
1G,5G
其他说明
保存于密闭容器内，置于干燥通风处。
储存分类代码
13 - Non Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
M P Gupta et al.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 29(1), 45-52 (1991-01-01)
Studies were performed on the mode of action of tolnaftate and resistance to this drug in Microsporum gypseum. Cells grown in the presence of tolnaftate (at the IC 50) showed a reduced content of total phospholipids and sterols whereas there
Tang Bo et al.
The journal of physical chemistry. B, 110(17), 8877-8884 (2006-04-28)
Based on the fact that tolnaftate degrade to beta-naphthol sodium (RONa) at 5.00 mol/L NaOH solution and RO(-) was protonated to ROH after being acidified and adjusted to the pH 4.50 by acetic acid-sodium acetate buffer solution, we studied and
H Yamaguchi et al.
The Japanese journal of antibiotics, 54(6), 323-330 (2001-08-28)
The therapeutic efficacy of a topical antifungal ointment containing 2% tolnaftate was studied in a guinea pig model of tinea pedis using the following four topical antifungal preparations commercially available as reference drugs: variotin (3,000 U/g ointment); phenyl-11-iodo-10-undecynoate (0.5% ointment);
R D Thompson et al.
Journal - Association of Official Analytical Chemists, 74(4), 603-607 (1991-07-01)
A liquid chromatographic (LC) method for the determination of the antifungal agent tolnaftate was developed. Isolation of the analyte was achieved by direct extraction or dilution with acetonitrile-water (80 + 20) followed by reverse-phase liquid chromatography using a C18 column.
A K Dash
Journal of microencapsulation, 14(1), 101-112 (1997-01-01)
Tolnaftate microcapsules and microspheres were prepared by gelatin-acacia coacervation and emulsion-solvent evaporation methods respectively. The physical state of the drug in these formulations was determined by using scanning electron microscopy (SEM), X-ray powder diffractometry, and differential scanning calorimetry (DSC). High
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