T7290
Tyrphostin 25
≥98%
别名:
(3,4,5-Trihydroxybenzylidene)malononitrile
方案
≥98%
效能
3 μM IC50
溶解性
DMSO: >50 mg/mL, clear, yellow to orange
储存温度
2-8°C
SMILES字符串
Oc1cc(cc(O)c1O)\C=C(\C#N)C#N
基因信息
human ... EGFR(1956)
应用
Tyrphostin 25 has been used for studying its effect on transcriptional repression induced by the adenoviral oncoprotein, E1a, in HeLa cells. Tyrphostin 25 has also been used to study the migration inhibition in IEC-6 cells.
生化/生理作用
EGFR tyrosine kinase inhibitor.
Tyrphostin 25 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
制备说明
Tyrphostin 25 is soluble in DMSO at a concentration that is greater than 50 mg/ml and yields a clear, yellow to orange solution.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Debjani Ghosh et al.
Bioscience reports, 22(3-4), 395-406 (2003-01-09)
In this study we show that protein tyrosine kinases (PTKs) and also protein tyrosine phosphatases are involved in the uptake of virulent and avirulent Leishmania donovani promastigotes by macrophage cells. Protein tyrosine kinase inhibitors such as genistein or tyrphostin 25
Maria Grazia Zizzo et al.
European journal of pharmacology, 521(1-3), 133-138 (2005-09-28)
The aim of this study was to investigate the signal transduction mechanisms underlying the inhibitory effect induced by pituitary adenylate cyclase activating peptide (PACAP-27) on the spontaneous contractile activity of longitudinal muscle of mouse ileum. Mechanical activity of ileal segments
Lian Hua Fang et al.
FEBS letters, 512(1-3), 282-286 (2002-02-20)
This study was undertaken to determine the role of tyrosine kinase on intracellular Ca(2+) ([Ca(2+)](i)), myosin light chain (MLC) phosphorylation, and contraction caused by norepinephrine (NE) in rat aorta. NE induced a sustained contraction with an increase of [Ca(2+)](i). On
Yu-Jing Gao et al.
Cardiovascular research, 71(2), 363-373 (2006-06-08)
Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS). In Wistar-Kyoto rats, rings of
Israel Rubinstein
Journal of applied physiology (Bethesda, Md. : 1985), 103(1), 184-189 (2007-04-14)
The purpose of this study was to determine whether protein tyrosine kinase, a ubiquitous family of intracellular signaling enzymes that regulates endothelial cell function, modulates bradykinin- and substance P-induced increase in macromolecular efflux from the intact hamster cheek pouch microcirculation.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持