T7770
茶碱
anhydrous, analytical standard
别名:
1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
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关于此项目
经验公式（希尔记法）:
C7H8N4O2
化学文摘社编号:
分子量:
180.16
EC Number:
200-385-7
UNSPSC Code:
41116107
PubChem Substance ID:
Beilstein/REAXYS Number:
13463
MDL number:
InChI key
ZFXYFBGIUFBOJW-UHFFFAOYSA-N
InChI
1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
SMILES string
CN1C(=O)N(C)c2[nH]cnc2C1=O
grade
analytical standard, anhydrous
packaging
vial of 250 mg
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
Gene Information
human ... PDE3A(5139), PDE4B(5142)
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General description
Theophylline is a naturally occurring alkaloid showing bronchodilator effects.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Theophylline may be used as a reference standard in the determination of theophylline in:
- blood and tissue samples using the spectrophotometric technique
- food, beverages and herbal products using high-performance liquid chromatography (HPLC)
- plasma samples using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV)
Biochem/physiol Actions
Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.
Packaging
Supplied in amber screw-cap vials
hcodes
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.
Schack AJ and Waxler HS
Journal of Pharmacology and Experimental Therapeutics, 97(3), 283-291 (1949)
A simple and rapid HPLC/UV method for the simultaneous quantification of theophylline and etofylline in human plasma.
Nirogi SVR, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 848(2), 271-276 (2007)
Dosage of theophylline in bronchial asthma.
Piafsky KM and Ogilvie IR
The New England Journal of Medicine, 292(23), 1218-1222 (1975)
Mazen Al-Alawi et al.
The American journal of medicine, 127(5), 370-378 (2014-01-02)
Global estimates on aging predict an increased burden of asthma in the older population. Consequently, its recognition, diagnosis, and management in clinical practice require optimization. This review aims to provide an update for clinicians, highlighting advances in the understanding of
F S F Ram et al.
Respiratory medicine, 99(2), 135-144 (2005-02-18)
To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD.
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