T7770
茶碱
anhydrous, analytical standard
别名:
1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
等级
analytical standard
anhydrous
包装
vial of 250 mg
技术
HPLC: suitable
gas chromatography (GC): suitable
包装形式
neat
SMILES字符串
CN1C(=O)N(C)c2[nH]cnc2C1=O
InChI
1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
InChI key
ZFXYFBGIUFBOJW-UHFFFAOYSA-N
基因信息
human ... PDE3A(5139), PDE4B(5142)
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一般描述
Theophylline is a naturally occurring alkaloid showing bronchodilator effects.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Theophylline may be used as a reference standard in the determination of theophylline in:
- blood and tissue samples using the spectrophotometric technique
- food, beverages and herbal products using high-performance liquid chromatography (HPLC)
- plasma samples using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV)
生化/生理作用
Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.
包装
Supplied in amber screw-cap vials
警示用语:
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.
Schack AJ and Waxler HS
Journal of Pharmacology and Experimental Therapeutics, 97(3), 283-291 (1949)
A simple and rapid HPLC/UV method for the simultaneous quantification of theophylline and etofylline in human plasma.
Nirogi SVR, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 848(2), 271-276 (2007)
Dosage of theophylline in bronchial asthma.
Piafsky KM and Ogilvie IR
The New England Journal of Medicine, 292(23), 1218-1222 (1975)
Rania O Salama et al.
Drug delivery and translational research, 4(3), 256-267 (2015-03-20)
A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an
Victoria Boswell-Smith et al.
The Journal of allergy and clinical immunology, 117(6), 1237-1243 (2006-06-06)
Theophylline has been relegated to a second- or even third-line therapy in the treatment of asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids and beta2-agonists, although recent findings have suggested that theophylline possesses anti-inflammatory and immunomodulatory effects in addition
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