T7783
Thonzonium bromide
别名:
Hexadecyl(2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl)dimethylammonium bromide
描述
cationic
分子量
591.71 g/mol
应用
sample preparation
SMILES字符串
Br.CCCCCCCCCCCCCCCC[N](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2
InChI
1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H
InChI key
PBWQBSCBSFJTLE-UHFFFAOYSA-N
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应用
Thonzonium bromide may be use to inhibit vacuolar ATPases (V-ATPases) to induce and study the effects of cytosolic acidification. Thonzonium bromide is also used to further characterize V-ATPases. Thonzonium bromide is use as a potential pDNA particle condenser.
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Ryosuke Suzuki et al.
Biological & pharmaceutical bulletin, 31(6), 1237-1243 (2008-06-04)
Non-viral DNA vectors are promising gene delivery systems and a variety of non-viral DNA vectors have been developed to date. Recently, we developed a novel non-viral gene delivery system--multifunctional envelope-type nano device (MEND). The MEND system has high transfection activity
A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection.
Gao Y, Gu W, Chen L, Xu Z, Li Y.
J. Controlled Release, 118, 381-388 (2007)
Chun-Yuan Chan et al.
The Journal of biological chemistry, 287(13), 10236-10250 (2012-01-05)
Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we conducted a high-throughput screen of a chemical library to search
Rebecca M Johnson et al.
Analytical biochemistry, 398(2), 203-211 (2009-12-19)
Fluorescence intensity of the pH-sensitive carboxyfluorescein derivative 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was monitored by high-throughput flow cytometry in living yeast cells. We measured fluorescence intensity of BCECF trapped in yeast vacuoles, acidic compartments equivalent to lysosomes where vacuolar proton-translocating ATPases (V-ATPases) are
Cristiana Lalli et al.
PLoS neglected tropical diseases, 9(1), e0003484-e0003484 (2015-01-31)
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple administration procedures and competitive cost and
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