T8067
T-0156
别名:
2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C31H29N5O7 · HCl
分子量:
620.05
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
SMILES string
Cl[H].COC(=O)C1=C(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3C(=O)N1Cc5ccnc(C)c5
color
white
solubility
DMSO: soluble, H2O: insoluble, methanol: soluble
storage temp.
2-8°C
Gene Information
human ... PDE5A(8654)
Application
T-0156 has been used to study the intracellular mobilization of calcium in HEK293 cells that transiently coexpressed either rat or human GPR35 and Gqi5.
Biochem/physiol Actions
Potent phosphodiesterase V (PDE5) inhibitor.
T-0156 can also inhibit PDE6.
Preparation Note
T-0156 is soluble in DMSO (17.3 mg/ml) and methanol. However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Yasuhito Taniguchi et al.
FEBS letters, 580(21), 5003-5008 (2006-08-29)
We found that zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, acted as an agonist for a G protein-coupled receptor, GPR35. In our intracellular calcium mobilization assay, zaprinast activated rat GPR35 strongly (geometric mean EC(50) value of 16nM), whereas it
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