T8067
T-0156
别名:
2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
颜色
white
溶解性
DMSO: soluble
H2O: insoluble
methanol: soluble
储存温度
2-8°C
SMILES字符串
Cl[H].COC(=O)C1=C(c2cc(OC)c(OC)c(OC)c2)c3ccnc(OCc4ncccn4)c3C(=O)N1Cc5ccnc(C)c5
基因信息
human ... PDE5A(8654)
应用
T-0156 has been used to study the intracellular mobilization of calcium in HEK293 cells that transiently coexpressed either rat or human GPR35 and Gqi5.
生化/生理作用
Potent phosphodiesterase V (PDE5) inhibitor.
T-0156 can also inhibit PDE6.
制备说明
T-0156 is soluble in DMSO (17.3 mg/ml) and methanol. However, it is insoluble in water.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Yasuhito Taniguchi et al.
FEBS letters, 580(21), 5003-5008 (2006-08-29)
We found that zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, acted as an agonist for a G protein-coupled receptor, GPR35. In our intracellular calcium mobilization assay, zaprinast activated rat GPR35 strongly (geometric mean EC(50) value of 16nM), whereas it
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