产品名称
抗-β微管蛋白III (神经元)抗体,小鼠单克隆 小鼠抗, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
2G10, monoclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa
种属反应性
human, mouse, rat
包装
antibody small pack of 25 μL
浓度
~1.0 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.25-0.5 μg/mL using PC12 cell extract
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
一般描述
微管蛋白 β 3 III类(TUBB3)也称 β-微管蛋白III,由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。
应用
小鼠抗β-微管蛋白III(神经元)单克隆抗体还可用于以下研究:
- 免疫荧光。
- 免疫细胞化学。
生化/生理作用
微管蛋白 β 3 III类(TUBB3)在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化(CFEOM3)和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中,TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长;因此,它是开发抗肿瘤药物的潜在靶标。
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
其他说明
免责声明
除非我们的产品目录或产品随附的其他公司文档中另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人或动物。
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
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