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T8578

Anti-β-Tubulin III Antibody

Name: Anti-β-Tubulin III Antibody
Brand: SIGMA

mouse monoclonal, 2G10

别名:

Anti-TUBB4, Anti-Tubb3, 抗-III类β-微管蛋白, 抗-微管蛋白β-4, 抗-微管蛋白β-III, 抗-微管蛋白，β−3, 抗-神经元特异性III类β-微管蛋白

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01323870

Conjugate:

unconjugated

Clone:

2G10, monoclonal

Application:

ICC, IHC, IP, WB

Citations:

258

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产品名称

抗-β微管蛋白III （神经元）抗体，小鼠单克隆小鼠抗, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

2G10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human, mouse, rat

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 0.25-0.5 μg/mL using PC12 cell extract, immunohistochemistry: suitable

isotype

IgG2a

UniProt accession no.

Q13509

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)

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General description

微管蛋白 β 3 III类（TUBB3）也称 β-微管蛋白III，由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。

Application

小鼠抗β-微管蛋白III（神经元）单克隆抗体还可用于以下研究：

免疫荧光。
免疫细胞化学。

Biochem/physiol Actions

微管蛋白 β 3 III类（TUBB3）在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化（CFEOM3）和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中，TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长；因此，它是开发抗肿瘤药物的潜在靶标。

Physical form

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

Disclaimer

除非我们的产品目录或产品随附的其他公司文档中另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人或动物。

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

低风险生物材料

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历史批次信息供参考:

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MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.

Li-Hua Sun et al.

Molecular neurodegeneration, 10, 36-36 (2015-08-12)

Previous studies have demonstrated that the trafficking defects of Nav1.1/Nav1.2 are involved in the dementia pathophysiology. However, the detailed mechanisms are not fully understood. Moreover, whether the impaired miRNAs regulation linked to dementia is a key player in sodium channel

A requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in culture.

Zhiqiang Zheng et al.

PloS one, 5(9), e12555-e12555 (2010-09-15)

Embryonic stem (ES) cells hold considerable promise as a source of cells with therapeutic potential, including cells that can be used for drug screening and in cell replacement therapies. Differentiation of ES cells into the somatic lineages is a regulated

Demethylation of specific Wnt/?-catenin pathway genes and its upregulation in rat brain induced by prenatal valproate exposure.

Wang Z

Anatomical Record (Hoboken, N.J. : 2007), 293(11), 1947-1953 (2010)

Highly efficient baculovirus-mediated multigene delivery in primary cells.

Maysam Mansouri et al.

Nature communications, 7, 11529-11529 (2016-05-05)

Multigene delivery and subsequent cellular expression is emerging as a key technology required in diverse research fields including, synthetic and structural biology, cellular reprogramming and functional pharmaceutical screening. Current viral delivery systems such as retro- and adenoviruses suffer from limited

Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture.

A Odawara et al.

Scientific reports, 6, 26181-26181 (2016-05-18)

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks

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全球贸易项目编号

货号	GTIN
T8578-200UL	04061837379383
T8578-100UL	04061837379376

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