产品名称
Tissue Inhibitor of Metalloproteinase-1 human, recombinant, expressed in CHO cells, ~500 μg/mL protein, buffered aqueous solution
生物来源
human
质量水平
重组
expressed in CHO cells
表单
buffered aqueous solution
分子量
~29 kDa
浓度
~500 μg/mL protein
技术
ELISA: suitable
immunoblotting: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... TIMP1(7076)
生化/生理作用
Plays a key role in maintaining the balance between extracellular matrix (ECM) deposition and degradation, and can inhibit angiogenesis, a crucial step in tumor invasion. TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.
TIMP-1 has greater binding efficiency to MMP-9, MMP-1, and MMP-3 than the other MMPs.
外形
Supplied in 0.01 M sodium phosphate buffer pH 7.3, 0.15 M NaCl.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Jiayin Peng et al.
Theriogenology, 84(9), 1636-1643 (2015-10-06)
Tissue inhibitors of metalloproteinases (TIMPs) are associated with several reproductive processes, such as mammalian follicular growth, ovulation, CL formation, and embryonic development. However, the expression and function of TIMPs in goat oviducts remain unclear. This work aimed to identify TIMP1
Gary J Litherland et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(8), 2175-2187 (2014-04-24)
To assess the role of glycogen synthase kinase 3 (GSK-3) as a regulator of cartilage destruction in human tissue and a murine model of osteoarthritis (OA). Surgical destabilization of the medial meniscus (DMM) was performed to induce experimental murine OA
Lena Vinther et al.
Protein expression and purification, 101, 157-164 (2014-07-08)
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is an endogenous inhibitor of matrix metalloproteinases (MMPs) with reported tumor promoting, as well as inhibitory, effects. These paradoxical properties are presumably mediated by different biological functions, MMP-dependent as well as -independent, and probably related
Chung-Han Tsai et al.
Nature communications, 5, 4804-4804 (2014-09-04)
Rab small GTPases are master regulators of membrane trafficking and guide vesicle targeting. Recent publications show that Rab-controlled trafficking pathways are altered during tumorigenesis. However, whether any of the Rabs plays a metastasis suppressor role is least explored. Here we
Ming-Ta Sung et al.
Oncology reports, 34(1), 439-446 (2015-05-09)
Krüppel-like factor 4 (KLF4) plays important roles in development, stemness and tumorigenesis; however limited information is available on the detailed function of KLF4 in hepatocellular carcinoma (HCC). The objective of the present study was to examine the functional roles of
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