T9197
Tissue Inhibitor of Metalloproteinase-3 人
>95% (SDS-PAGE), recombinant, expressed in BHK cells, buffered aqueous solution
别名:
TIMP-3
recombinant
expressed in BHK cells
assay
>95% (SDS-PAGE)
form
buffered aqueous solution
mol wt
glycosylated form ~30 kDa, ~23 kDa (unglycosylated form)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TIMP3(7078)
Biochem/physiol Actions
The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.
Physical form
Supplied in acitve form, in 10 mM MES, pH 5.0, 100 mM sodium chloride, 0.02% Brij-35 and 50% glycerol.
法规信息
新产品
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M L Sulis et al.
Leukemia, 25(10), 1564-1569 (2011-06-01)
Oncogenic mutations in NOTCH1 are present in over 50% of T-cell lymphoblastic leukemias (T-ALLs). Activation of NOTCH1 requires a double proteolytic processing in the extracellular region of the receptor (S2) and in the transmembrane domain (S3). Currently, anti-NOTCH1 therapies based
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