重组
expressed in BHK cells
方案
>95% (SDS-PAGE)
表单
buffered aqueous solution
分子量
glycosylated form ~30 kDa
~23 kDa (unglycosylated form)
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... TIMP3(7078)
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生化/生理作用
The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.
外形
Supplied in acitve form, in 10 mM MES, pH 5.0, 100 mM sodium chloride, 0.02% Brij-35 and 50% glycerol.
法规信息
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M L Sulis et al.
Leukemia, 25(10), 1564-1569 (2011-06-01)
Oncogenic mutations in NOTCH1 are present in over 50% of T-cell lymphoblastic leukemias (T-ALLs). Activation of NOTCH1 requires a double proteolytic processing in the extracellular region of the receptor (S2) and in the transmembrane domain (S3). Currently, anti-NOTCH1 therapies based
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