生物来源
mouse
重组
expressed in E. coli
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.66 μg/mL
分子量
16-17 kDa by SDS-PAGE (doublet)
predicted mol wt ~14 kDa
包装
pkg of 25 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Ccl25(20300)
应用
The interaction of TECK and its receptor CCR9 plays a pivotal role in recruiting the developing thymocytes to their distinct compartment of the thymus.
生化/生理作用
TECK, a CC chemokine, is chemotactic for activated macrophages, dendritic cells, and thymocytes.
Thymus-expressed chemokine (TECK) belongs to CC chemokine and is expressed mainly in thymus and small intestine. It can facilitate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. Further, TECK potentially assists in T Cell Development.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing at least 50 μg bovine serum albumin per 1 μg of cytokine.
分析说明
The biological activity is measured by its ability to chemoattract hCCR9 transfected BaF/3 cells.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
M A Wurbel et al.
European journal of immunology, 30(1), 262-271 (1999-12-22)
Chemokines are key regulators of migration in lymphoid tissues. In the thymus, maturing thymocytes move from the outer capsule to the inner medulla and thereby interact with different types of stromal cells that control their maturation and selection. In the
B A Zabel et al.
The Journal of experimental medicine, 190(9), 1241-1256 (1999-11-02)
TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on
A P Vicari et al.
Immunity, 7(2), 291-301 (1997-08-01)
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was
Siying Zhu et al.
PloS one, 9(6), e100167-e100167 (2014-06-18)
Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural killer cells and T cells. These cells might have an important role in the pathogenesis of ulcerative colitis (UC). The interaction of chemokine ligand 25 (CCL25)
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