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Merck
CN

U0633

尿激酶 来源于人类尿液

lyophilized powder, ≥500 units/mg protein

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352204
eCl@ss:
32160410
EC Number:
232-917-9
NACRES:
NA.54
MDL number:
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form

lyophilized powder

Quality Level

specific activity

≥500 units/mg protein

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PLAU(5328)

General description

高分子量形式在非还原条件下通过 SDS-PAGE 以 54kDa 迁移

Biochem/physiol Actions

尿激酶表达和尿胰蛋白酶抑制剂的侵袭性抑制通过 MEK/ERK/c-Jun 依赖性信号通路起作用。

Physical form

冻干品,来自含有 100 mM NaCl,0.1%PEG 6000 和 200 mM 甘露醇的 1 mL 50 mM Tris-HCl 溶液(pH 7.4)

Other Notes

在 pH7.5,37℃ 下,一个单位的酶每分钟将激活纤溶酶原产生每毫升 1.0 ΔA275 (测量来自 α-酪蛋白(1 cm 光路)的高氯酸可溶性产物)。

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

高风险级别生物产品--人源产品

此项目有


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jordan R Yaron et al.
Methods in molecular biology (Clifton, N.J.), 2225, 107-123 (2020-10-28)
Viruses have devised highly effective approaches that modulate the host immune response, blocking immune responses that are designed to eradicate viral infections. Over millions of years of evolution, virus-derived immune-modulating proteins have become extraordinarily potent, in some cases working at
H Kobayashi et al.
The Journal of biological chemistry, 276(3), 2015-2022 (2000-10-26)
Urinary trypsin inhibitor (UTI), a Kunitz-type protease inhibitor, interacts with cells as a negative modulator of the invasive cells. Human ovarian cancer cell line, HRA, was treated with phorbol ester (PMA) to evaluate the effect on expression of urokinase-type plasminogen
Xiaojian Tang et al.
International journal of biological sciences, 9(1), 55-66 (2013-01-05)
Gastric cancer (GC) remains a leading cause of death worldwide, and an elevated expression of osteopontin (OPN) may correlate with its poor survival. Alternative splicing of OPN can result in three isoforms, OPN-a, OPN-b and OPN-c. The aim of our
A Santillo et al.
Journal of dairy science, 105(11), 8609-8620 (2022-09-30)
The aim of the present study was to assess the dietary supplementation of tannins to grazing dairy cows in 2 seasons characterized by a good quality pasture (spring) or a poor-quality pasture (summer). The effects of dietary tannins were assessed
Sylwia Małgorzewicz et al.
International journal of molecular medicine, 31(3), 503-510 (2013-01-15)
Plasminogen activator inhibitor type-1 (PAI-1) inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which convert plasminogen to plasmin, a strong proteolytic enzyme. Thus, PAI-1 is a primary and negative regulator of plasmin-driven proteolysis. In addition to its main

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