U106
(−)-cis-(1S,2R)-U-50488 tartrate
solid
别名:
(−)-(1S,2R)-cis-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide tartrate
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关于此项目
经验公式（希尔记法）:
C19H26Cl2N2O · C4H6O6
化学文摘社编号:
分子量:
519.42
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C19H26Cl2N2O.C4H6O6/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;5-1(3(7)8)2(6)4(9)10/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t17-,18+;/m0./s1
SMILES string
OC(C(O)C(O)=O)C(O)=O.CN([C@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI key
DMBKHRMAGYYBJM-CJRXIRLBSA-N
form
solid
color
white
solubility
ethanol: soluble
storage temp.
2-8°C
Gene Information
human ... OPRS1(10280)
Biochem/physiol Actions
Potent σ receptor ligand.
Preparation Note
(-)-cis-(1S,2R)-U-50488 tartrate is soluble in ethanol.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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Thiago M Cunha et al.
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B R de Costa et al.
Journal of medicinal chemistry, 32(8), 1996-2002 (1989-08-01)
The synthesis and in vitro sigma receptor activity of the two diastereomers of U50,488 [(+/-)-2], namely, (1R,2S)-(+)- cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet ami de [(+)-1] and (1S,2R)-(-)-cis-3,4-dichloro- N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide [(-)-1], are described. (+)-1 and (-)-1 were synthesized from (+/-)-trans-N-methyl-2-aminocyclohexanol [(+/-)-3]. Pyridinium chlorochromate (PCC) oxidation of
JiaJi Lin et al.
Cytokine, 61(3), 842-848 (2013-02-14)
It is well documented that the Toll-like receptor 4 (TLR4)/NF-κB signaling mediates early inflammation during myocardial ischemia and reperfusion. Our previous study has demonstrated that κ-opioid receptor stimulation with U50,488H produces cardioprotective and anti-inflammatory effects. The aim of the present
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