U1755
Urapidil
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关于此项目
经验公式（希尔记法）:
C20H29N5O3
化学文摘社编号:
分子量:
387.48
UNSPSC Code:
12352204
PubChem Substance ID:
EC Number:
252-130-4
MDL number:
SMILES string
COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
InChI
1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3
InChI key
ICMGLRUYEQNHPF-UHFFFAOYSA-N
Biochem/physiol Actions
α-Adrenergic antagonist; peripheral vasodilator;
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
B Tomlinson et al.
European journal of clinical pharmacology, 41(1), 1-3 (1991-01-01)
Intravenous urapidil, 40 mg bolus followed by an infusion of 18 mg.h-1 for 2 h was administered to 6 female non-patient volunteers. Randomised cumulative dose response curves to angiotensin, phenylephrine and isoprenaline were performed before and commencing 30 min after
Zhi Wang et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 31(2), 317-319 (2011-03-01)
To compare the clinical efficacy and safety of sublingual nifedipine and intravenous urapidil in the treatment of acute postoperative hypertension. The clinical data of 215 patients with APH after tumorectomy were retrospectively analyzed, among whom 165 were treated with sublingual
L O Minushkina
Kardiologiia, 52(8), 77-82 (2012-10-27)
The review considers the possibility of using capsule form urapidila for combination therapy for treatment-resistant hypertension. The drug has a dual mechanism of action and combining the properties of -blockers and centrally acting drug, has a high efficiency, comparable to