U4760
UR-AK57 dihydrochloride
≥98% (HPLC)
别名:
N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)-propyl]guanidine dihydrochloride
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关于此项目
经验公式（希尔记法）:
C17H29N5O·2HCl
化学文摘社编号:
分子量:
392.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
UR-AK57 dihydrochloride, ≥98% (HPLC)
InChI key
IBBYQLOGMIDRMM-UHFFFAOYSA-N
SMILES string
Cl.Cl.CC(CC(=O)NC(=N)NCCCc1ncc[nH]1)C2CCCCC2
InChI
1S/C17H29N5O.2ClH/c1-13(14-6-3-2-4-7-14)12-16(23)22-17(18)21-9-5-8-15-19-10-11-20-15;;/h10-11,13-14H,2-9,12H2,1H3,(H,19,20)(H3,18,21,22,23);2*1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine.
Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine. Histamine receptors are GPCRS and have long been therapeutic targets for allergic rhinitis. In brain, histamine receptors are targets for psychotherapeutics.
UR-AK57 is known to function as an effective, partial histamine H1-receptor (H1R) and H2-receptor (H2R) agonist.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
UR-AK57 dihydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sheng-Xue Xie et al.
The Journal of pharmacology and experimental therapeutics, 317(3), 1262-1268 (2006-03-24)
Both the histamine H1-receptor (H1R) and H2-receptor (H2R) exhibit pronounced species selectivity in their pharmacological properties; i.e., bulky agonists possess higher potencies and efficacies at guinea pig (gp) than at the corresponding human (h) receptor isoforms. In this study, we
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