U4760
UR-AK57 dihydrochloride
≥98% (HPLC)
别名:
N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)-propyl]guanidine dihydrochloride
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关于此项目
经验公式（希尔记法）:
C17H29N5O·2HCl
化学文摘社编号:
分子量:
392.37
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.Cl.CC(CC(=O)NC(=N)NCCCc1ncc[nH]1)C2CCCCC2
InChI
1S/C17H29N5O.2ClH/c1-13(14-6-3-2-4-7-14)12-16(23)22-17(18)21-9-5-8-15-19-10-11-20-15;;/h10-11,13-14H,2-9,12H2,1H3,(H,19,20)(H3,18,21,22,23);2*1H
InChI key
IBBYQLOGMIDRMM-UHFFFAOYSA-N
生化/生理作用
Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine.
Histamine receptors are ubiquitously expressed and activated endogenously by the neurotransmitter histamine. Histamine receptors are GPCRS and have long been therapeutic targets for allergic rhinitis. In brain, histamine receptors are targets for psychotherapeutics.
UR-AK57 is known to function as an effective, partial histamine H1-receptor (H1R) and H2-receptor (H2R) agonist.
特点和优势
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
UR-AK57 dihydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Sheng-Xue Xie et al.
The Journal of pharmacology and experimental therapeutics, 317(3), 1262-1268 (2006-03-24)
Both the histamine H1-receptor (H1R) and H2-receptor (H2R) exhibit pronounced species selectivity in their pharmacological properties; i.e., bulky agonists possess higher potencies and efficacies at guinea pig (gp) than at the corresponding human (h) receptor isoforms. In this study, we
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