产品名称
抗UCP-1 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~32 kDa
species reactivity
mouse, human, rat
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using protease-digested sections of mouse brown adipose tissue.
western blot: 1:1,000 using mitochondrial extract of rat brown adipose tissue
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UCP1(7350)
mouse ... Ucp1(22227)
rat ... Ucp1(24860)
General description
解偶联蛋白(UCP1)是一种32 kDa的线粒体内膜蛋白。它作为形成二聚体的质子通道具有活性。它可以结合嘌呤核苷酸，并且能够被脂肪酸激活。
Immunogen
该合成肽与KLH偶联，其对应于具有N末端半胱氨酸的人UCP1序列（氨基酸145-159）。在大鼠和小鼠UCP1中的相应序列是相同的。
Physical form
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
Application
兔抗UCP-1抗体可用于免疫印迹和免疫组化。
Biochem/physiol Actions
UCP-1抗体能够特异性识别人、小鼠和大鼠的UCP-1。免疫肽能够特异性抑制UCP-1条带的染色。被抗体识别的表位能够耐受常规的福尔马林固定和石蜡包埋。
解偶联蛋白(UCP)是氧化磷酸化酶促解偶联剂的转运蛋白。它们能够将由呼吸链泵出的质子送回到线粒体基质中。UCP-1仅在啮齿类动物和新生儿的褐色脂肪组织(BAT)中，其中，它受去甲肾上腺素和甲状腺激素的调节。UCP-1依赖于一种必需的辅因子——CoQ（泛醌）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
此项目有
The chemical uncoupler 2, 4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality
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Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT
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Biochimie, 134(12), 35-35 (2017)
Towards a molecular understanding of adaptive thermogenesis
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Nature, 404(6778), 652-660 (2000)
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van den Beukel JC, et al.
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