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U6756

U-73122 水合物

Name: U-73122 水合物
Brand: SIGMA

≥97.5% (HPLC), phospholipase C inhibitor, powder

别名:

1- [6-[（（17β）-3- Methoxyestra-1，3，5[10]-三烯-17-基）氨基]己基] -1H-吡咯-2，5-二酮

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关于此项目

经验公式（希尔记法）:

C₂₉H₄₀N₂O₃ · xH₂O

化学文摘社编号:

112648-68-7

分子量:

464.64 (anhydrous basis)

UNSPSC Code:

41106300

PubChem Substance ID:

24278065

NACRES:

NA.77

MDL number:

MFCD12910450

Assay:

≥97.5% (HPLC)

Form:

powder

Quality level:

100

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产品名称

U-73122 水合物, powder

assay

≥97.5% (HPLC)

Quality Level

100

form

powder

color

off-white

solubility

ethanol: ~0.7 mg/mL, DMSO: ~0.9 mg/mL, chloroform: ~10 mg/mL, DMSO: ≤2.6 mg/mL (Achieved with heating.), ethanol: ≤5 mg/mL (Achieved with heating.), H₂O: insoluble

storage temp.

room temp

SMILES string

O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O

InChI

1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1

InChI key

WCOYJDRCHHGMRK-BDEPKWELSA-N

Application

U-73122 水合物已用于研究磷脂酶C（PLC）信号在调节沙鼠 Reissner′s 膜（RM）中的上皮 Na⁺通道（ENaC）功能中的作用。U-73122 还用于研究人脐静脉内皮细胞（HUVEC）中的局部钙反应。

Biochem/physiol Actions

抑制 PPI 水解成 IP₃，导致细胞溶质游离钙的减少。抑制 G蛋白- 磷脂酶C 活化的偶联，同时保持不受 cAMP 产生的影响。

Features and Benefits

该化合物在受体分类和信号转导手册的磷脂酶C 页面上有重点介绍。想要浏览手册的其他页面，请单击此处。

Preparation Note

U-73122 水合物可溶于乙醇（约 0.7 mg/ml或加热时，≤ 5mg/ml）、氯仿（约 10 mg/ml）和DMSO（约 0.9 mg/ml或加热时，≤ 2.6mg/ml）。U-73122 水合物不溶于水。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000455133

0000445003

0000153720

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U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

D I Yule et al.

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Stimulation of rat pancreatic acinar cells with low concentrations of phosphatidylinositol (PI)-linked secretagogues induces [Ca2+]i oscillations, without measurable changes in the formation of inositol 1,4,5-trisphosphate. Therefore, we tested U73122 a new phospholipase C inhibitor to determine if PI turnover is

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

J E Bleasdale et al.

The Journal of pharmacology and experimental therapeutics, 255(2), 756-768 (1990-11-01)

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U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells.

R C Smallridge et al.

Endocrinology, 131(4), 1883-1888 (1992-10-01)

TRH increases cytosolic-free calcium ([Ca2+]i) by activating phospholipase C(PL-C), which induces phosphoinositol hydrolysis, leading to Ca2+ mobilization from inositol trisphosphate (IP3) sensitive stores, and by increasing Ca2+ influx. Increases in [Ca2+]i stimulate PRL secretion. We investigated the effects of U-73122

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货号	GTIN
U6756-5MG	04061837410000

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