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Merck
CN

U7253

Urotensin I teleost fish

≥95% (HPLC)

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经验公式(希尔记法):
C210H340N62O67S2
化学文摘社编号:
分子量:
4869.45
UNSPSC Code:
12352200
MDL number:
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assay

≥95% (HPLC)

storage temp.

−20°C

Application

Urotensin I teleost fish was administered intracerebroventricularly in juvenile rainbow trout (Oncorhynchus mykiss) for studying the impact of corticotropin-releasing factor (CRF) and urotensin I on aggression and anxiety-like behaviour.

Biochem/physiol Actions

A neuroendocrine peptide of the CRF family that is found in the brain of most fish species. It may be involved in the regulation of blood pressure in fish. It is closely related to mammalian urocortin and releases ACTH from cultured rat pituitary cells.
Urotensin I is a CRF-like neuropeptide, expresses mainly in the brain of most fish species. It induces the acetylcholine (ACTH) release from the superfused goldfish anterior pituitary cell column. It stimulates the marked, dose-dependent reduction in perfusion pressure in the hind limb of the rat.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tobias Backström et al.
The Journal of experimental biology, 214(Pt 6), 907-914 (2011-02-25)
Corticotropin-releasing factor (CRF) is central in the stress response but also modulates several behaviors including anxiety-related behaviors and aggression. In this study, juvenile rainbow trout (Oncorhynchus mykiss) were tested for competitive ability, determined during dyadic fights for dominance, after intracerebroventricular
N Mimassi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 279(2), R484-R491 (2000-08-12)
The cardiovascular effects of centrally and peripherally administered synthetic trout urotensin (U)-I, a member of the corticotropin-releasing hormone family of neuroendocrine peptides, were investigated in unanesthetized rainbow trout Oncorhynchus mykiss. Intracerebroventricular injections of U-I (5.0 and 12.5 pmol) produced a
Effects and assay of urotensin I on the perfused hind limb of the rat.
K Lederis et al.
General and comparative endocrinology, 24(1), 10-16 (1974-09-01)
J Fryer et al.
Endocrinology, 113(6), 2308-2310 (1983-12-01)
Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion
J M Conlon
Regulatory peptides, 93(1-3), 3-12 (2000-10-18)
During the past 20 years, several bioactive peptides have been identified in teleost fishes that subsequently have been shown to play important regulatory roles in mammalian physiology. The urophysis, corpuscles of Stannius and Brockmann body are anatomical structures particular to

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