U7504
UDP-Glucuronosyltransferase 1A7 Isozyme human
recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution, ≥0.15 units/mg protein
别名:
UDP-glycosyltransferase, UGT1A7
重组
expressed in baculovirus infected Sf9 cells
表单
buffered aqueous glycerol solution
比活
≥0.15 units/mg protein
浓度
2-20 mg/mL protein
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... UGT1A7(54577)
一般描述
Greater than 80% of the activity was observed after the microsomes had undergone five freeze-thaw cycles.
UGT1A7 catalyzes the glucuronidation of phenolic xenobiotics.
生化/生理作用
A family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.
外形
Microsomal fraction in 100 mM potassium phosphate, pH 7.4, 20% (v/v) glycerol, 0.1 mM EDTA, 1 mM DTT
其他说明
One unit will transfer one nanomole of glucuronic acid from uridine-5′-diphosphoglucuronic acid to octyl gallate per minute at pH 7.5 at 37 °C.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
[Meulengracht disease].
Jonas Zeitz et al.
Praxis, 102(3), 129-135 (2013-02-07)
UGT2B17 as a disease accelerator in CLL.
Yiming Zhong et al.
Blood, 121(7), 1067-1068 (2013-02-16)
Hye Young Ji et al.
Archives of pharmacal research, 36(1), 1-5 (2013-02-02)
DA-9801, the mixture extract of Dioscoreae rhizoma and Dioscorea nipponica Makino, is a new herbal drug currently being evaluated in a phase II clinical study for the treatment of diabetic peripheral neuropathy in Korea. The inhibitory potentials of DA-9801, D.
Cong Liu et al.
Fitoterapia, 83(8), 1415-1419 (2013-01-23)
Deoxyschizandrin and schisantherin A are major bioactive lignans isolated from Fructusschisandrae which has been widely used as a tonic in traditional Chinese medicine for manyyears. Inhibition of UDP-glucuronosyltransferases (UGTs) by herbal components might be animportant reason for clinical herb–drug interaction.
Cyril Bigo et al.
Drug metabolism reviews, 45(1), 34-47 (2013-01-22)
The recent progresses in molecular biology and pharmacology approaches allowed the characterization of a series of nuclear receptors (NRs) as efficient regulators of uridine diphosphate glucuronosyltransferase (UGT) genes activity. These regulatory processes ensure an optimized UGT expression in response to
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