recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
47 kDa
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... UBE2D1(7321), UBE2N(7334)
General description
Manufactured for Sigma by Boston Biochem., Inc.
Biochem/physiol Actions
Human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer.
Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.
Physical form
Solution in 50 mM HEPES, pH 8.0, 100 mM NaCl, 1 mM DTT in 10% glycerol.
存储类别
12 - Non Combustible Liquids
法规信息
新产品
此项目有
The ubiquitin-proteasome proteolytic pathway.
A Ciechanover
Cell, 79(1), 13-21 (1994-10-07)
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