生物来源
human
质量水平
重组
expressed in E. coli (GST-tagged)
方案
≥95% (SDS-PAGE)
表单
solution
分子量
47 kDa
技术
ligand binding assay: suitable
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... UBE2D3(7323)
一般描述
Manufactured for Sigma by Boston Biochem., Inc.
应用
Ubiquitin-Carrier Protein H5c human may be used to study ubiquitin-proteasome system and its role in pathogenesis of human diseases.
生化/生理作用
Human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer.
Mediates degradation of a myriad of short-lived regulatory proteins such as tumor suppressor p53.
Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.
Ubiquitin-Carrier Protein H5c human also referred to as UbcH5c is a recombinant protein that interacts with ZIPK and stimulate its ubiquitination and hence facilitates in regulating ZIPK accumulation in promyelocytic leukemia protein nuclear body (PML-NBs).
外形
Solution in 50 mM HEPES, pH 7.6, 50 mM NaCl, 1 mM DTT in 10% glycerol.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Norihiko Ohbayashi et al.
Biochemical and biophysical research communications, 372(4), 708-712 (2008-06-03)
Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. In our previous study, we showed that leukemia inhibitory factor stimulated threonine-265 phosphorylation
H Gonen et al.
The Journal of biological chemistry, 274(21), 14823-14830 (1999-05-18)
The last step in the activation of the transcription factor NF-kappaB is signal-induced, ubiquitin- and proteasome-mediated degradation of the inhibitor IkappaBalpha. Although most of the components involved in the activation and degradation pathways have been identified, the ubiquitin carrier proteins
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