UC223
10-羟基华法林
别名:
4-Dihydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
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关于此项目
经验公式（希尔记法）:
C19H16O5
化学文摘社编号:
分子量:
324.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI
1S/C19H16O5/c1-11(20)17(21)15(12-7-3-2-4-8-12)16-18(22)13-9-5-6-10-14(13)24-19(16)23/h2-10,15,17,21-22H,1H3
SMILES string
CC(=O)C(O)C(c1ccccc1)C2=C(O)c3ccccc3OC2=O
InChI key
BPZSPAZBZFZZBN-UHFFFAOYSA-N
form
solid
color
colorless
mp
183-185 °C
solubility
DMSO: soluble, methanol: soluble
storage temp.
2-8°C
Application
10-Hydroxywarfarin has been used for stereo-specific metabolic studies. 10-Hydroxywarfarin has also been used to study its inhibitory effects on CYP2C9.
Biochem/physiol Actions
Major CYP3A4 metabolite of (R)-warfarin.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
10-Hydroxywarfarin is soluble in methanol and DMSO.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Eye Dam. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
R F Lawrence et al.
Chirality, 2(2), 96-105 (1990-01-01)
The synthesis of a diastereomerically pure 10-hydroxywarfarin [4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1 benzopyran-2-one] was accomplished in three steps from racemic warfarin. The relative configuration of the synthetic product was established by conversion to a cyclic derivative followed by NMR and X-ray diffraction analysis. Absolute
Z Y Zhang et al.
Analytical biochemistry, 298(1), 40-49 (2001-10-25)
A sensitive assay using high-performance liquid chromatography tandem mass spectrometry (MS/MS) has been established for the quantitative analysis of cytochrome P450 form-specific activities using warfarin as a probe substrate. Four metabolites, 6-, 7-, 8-, and 10-hydroxywarfarin, were chromatographically resolved within
Drew R Jones et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(15-16), 1056-1062 (2011-04-08)
Coumadin (R/S-warfarin) is a commonly prescribed anticoagulant for over ∼20 million Americans. Although highly efficacious, positive clinical outcomes during warfarin therapy depend on maintaining a narrow therapeutic range for the drug. This goal is challenging due to large inter-individual variability
Jie Zhang et al.
Journal of chromatography. A, 1082(2), 235-239 (2005-07-23)
The use of capillary electrophoresis (CE) for the determination of cytochrome P450 3A4 (CYP3A4) activity with R-warfarin as a substrate was investigated. CYP3A4 activity was determined by the quantitation of the product, 10-hydroxywarfarin, based on separation by CE. The separation
Kazuki Takeda et al.
Pesticide biochemistry and physiology, 148, 42-49 (2018-06-13)
Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. However
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