UC223
10-羟基华法林
别名:
4-Dihydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
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关于此项目
经验公式（希尔记法）:
C19H16O5
化学文摘社编号:
分子量:
324.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI
1S/C19H16O5/c1-11(20)17(21)15(12-7-3-2-4-8-12)16-18(22)13-9-5-6-10-14(13)24-19(16)23/h2-10,15,17,21-22H,1H3
SMILES string
CC(=O)C(O)C(c1ccccc1)C2=C(O)c3ccccc3OC2=O
InChI key
BPZSPAZBZFZZBN-UHFFFAOYSA-N
form
solid
color
colorless
mp
183-185 °C
solubility
DMSO: soluble, methanol: soluble
storage temp.
2-8°C
Application
10-Hydroxywarfarin has been used for stereo-specific metabolic studies. 10-Hydroxywarfarin has also been used to study its inhibitory effects on CYP2C9.
Biochem/physiol Actions
Major CYP3A4 metabolite of (R)-warfarin.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
10-Hydroxywarfarin is soluble in methanol and DMSO.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Eye Dam. 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
R F Lawrence et al.
Chirality, 2(2), 96-105 (1990-01-01)
The synthesis of a diastereomerically pure 10-hydroxywarfarin [4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1 benzopyran-2-one] was accomplished in three steps from racemic warfarin. The relative configuration of the synthetic product was established by conversion to a cyclic derivative followed by NMR and X-ray diffraction analysis. Absolute
Darja Herman et al.
European journal of clinical pharmacology, 62(4), 291-296 (2006-03-23)
Warfarin is a frequently used anticoagulant drug with narrow therapeutic index and high interindividual variability in the dose requirement. We have previously shown that warfarin dose is influenced by cytochrome P450 (CYP) 2C9 genotype, age, body weight and co-treatment with
Kazuki Takeda et al.
Pesticide biochemistry and physiology, 134, 1-7 (2016-12-05)
Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many reports regarding mutations of vitamin K epoxide reductase
Jie Zhang et al.
Journal of chromatography. A, 1082(2), 235-239 (2005-07-23)
The use of capillary electrophoresis (CE) for the determination of cytochrome P450 3A4 (CYP3A4) activity with R-warfarin as a substrate was investigated. CYP3A4 activity was determined by the quantitation of the product, 10-hydroxywarfarin, based on separation by CE. The separation
Drew R Jones et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(15-16), 1056-1062 (2011-04-08)
Coumadin (R/S-warfarin) is a commonly prescribed anticoagulant for over ∼20 million Americans. Although highly efficacious, positive clinical outcomes during warfarin therapy depend on maintaining a narrow therapeutic range for the drug. This goal is challenging due to large inter-individual variability
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