InChI key
YMCWOAZGWMZGQT-FPNLOETNSA-N
InChI
1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h9,13-17,21-22H,3-8,10H2,1-2H3/t13-,14+,15+,16-,17+,18+,19+/m1/s1
form
powder
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
mp
192-194 °C
storage temp.
2-8°C
Application
16αHydroxytestosterone has been used as a reference standard for the evaluation of testosterone metabolites using ultra-performance liquid chromatography/tandem mass spectrometric (UPLC/MS/MS) techniques. This product has also been used to analyze the developmental profiles of testosterone hydroxylases in chickens.
Biochem/physiol Actions
CYP2C11 (rat) metabolite; androgenic
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
K Sugiyama et al.
Drug metabolism and disposition: the biological fate of chemicals, 22(4), 584-591 (1994-07-01)
P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16 alpha-hydroxyandrostenedione. Because Waxman (J. Biol. Chem. 259, 15481-15490) has reported that the enzyme converts androstenedione to 16
T L Klug et al.
Molecular genetics and metabolism, 89(4), 381-389 (2006-09-19)
Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16alpha-hydroxyestrone (16alphaOHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the
Ganfeng Wang et al.
Rapid communications in mass spectrometry : RCM, 20(14), 2215-2221 (2006-06-23)
This paper describes the development and partial validation of a fast, sensitive and specific ultra-performance liquid chromatography/tandem mass spectrometric (UPLC/MS/MS) method for the determination of testosterone (T) and its four metabolites, 6beta-OH-T, 16alpha-OH-T, 16beta-OH-T and 2alpha-OH-T, in in vitro samples.
M Paolini et al.
British journal of pharmacology, 122(2), 344-350 (1997-10-06)
1. The sensitivity of the developing embryo to xenobiotics is highly dependent on the expression of metabolizing enzymes including cytochromes P450 (CYP). In the present study, therefore, the ontogeny of the CYP-dependent system in the chick was investigated with testosterone
M Numazawa et al.
Analytical biochemistry, 146(1), 75-81 (1985-04-01)
A sensitive nonradiometric assay of aromatization of 16 alpha-hydroxylated androgens, 16 alpha-hydroxy-4-androstene-3,17-dione (16 alpha-OHA), and 16 alpha-hydroxytestosterone (16 alpha-OHT), has been developed using reverse-phase high-performance liquid chromatography with voltametric detector. The estrogens produced by human placental microsomes, estriol (E3) and
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