UC289
16β-Hydroxytestosterone
别名:
16β,17β-Dihydroxyandrost-4-en-3-one, 4-Androstene-16β,17β-diol-3-one
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关于此项目
经验公式（希尔记法）:
C19H28O3
化学文摘社编号:
分子量:
304.42
UNSPSC Code:
12161501
PubChem Substance ID:
MDL number:
InChI
1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h9,13-17,21-22H,3-8,10H2,1-2H3/t13-,14+,15+,16+,17+,18+,19+/m1/s1
SMILES string
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1C[C@H](O)[C@@H]2O
InChI key
YMCWOAZGWMZGQT-KYQPOWKGSA-N
form
powder
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
mp
184-186
storage temp.
2-8°C
Application
16β-Hydroxytestosterone can be used as a standard for chromatographic assays of testosterone hydroxylases.
Biochem/physiol Actions
CYP3A2/2B1 (rat) metabolite; androgenic
signalword
Danger
hcodes
pcodes
Hazard Classifications
Carc. 2 - Repr. 1B
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
H B Lim et al.
Biochemistry international, 28(3), 543-550 (1992-11-01)
The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene-
K Sugiyama et al.
Drug metabolism and disposition: the biological fate of chemicals, 22(4), 584-591 (1994-07-01)
P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16 alpha-hydroxyandrostenedione. Because Waxman (J. Biol. Chem. 259, 15481-15490) has reported that the enzyme converts androstenedione to 16
T L Klug et al.
Molecular genetics and metabolism, 89(4), 381-389 (2006-09-19)
Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16alpha-hydroxyestrone (16alphaOHE1) ratio are at reduced risk for breast cancer and have a better prognosis. The aim was to identify factors associated with the
M Numazawa et al.
Analytical biochemistry, 146(1), 75-81 (1985-04-01)
A sensitive nonradiometric assay of aromatization of 16 alpha-hydroxylated androgens, 16 alpha-hydroxy-4-androstene-3,17-dione (16 alpha-OHA), and 16 alpha-hydroxytestosterone (16 alpha-OHT), has been developed using reverse-phase high-performance liquid chromatography with voltametric detector. The estrogens produced by human placental microsomes, estriol (E3) and
M Ringel et al.
Xenobiotica; the fate of foreign compounds in biological systems, 32(8), 653-666 (2002-09-26)
1. Steroids are known to act as permissive factors in hepatocytes. This study shows that dexamethasone (DEX) is a permissive factor for induction of CYP2B1/2, CYP3A1, CYP2A1 and probably also CYP2C11 in cultures with primary rat hepatocytes. 2. The induction
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