V2005
[去苯甲酰基-1, Val4, D-Arg8]-加压素
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C48H69N13O11S2
化学文摘社编号:
分子量:
1068.27
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC(C)C1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC(=O)CC(C)(C)SSCC(NC(=O)C(CC(N)=O)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
Agonist at the V2 vasopressin receptor (antidiuretic) and antagonist at the V1 receptor (vasopressor).
D L Chen et al.
Journal of reproduction and fertility, 102(2), 337-343 (1994-11-01)
This paper describes further pharmacological characterization of the decidual prostaglandin-releasing oxytocin receptors and the myometrial uterotonic oxytocin receptors in the uterus of the pregnant rat. The effects of oxytocin, arginine-vasopressin and their related agonists and antagonists on the release of
P F Mento et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 175(1), 58-63 (1984-01-01)
The roles of arginine vasopressin (AVP), the sympathetic nervous system, and the renin-angiotensin system in maintaining elevated blood pressure in established DOC-salt hypertension in rats were studied by injection of specific antagonists of these systems. The specific AVP antagonist dPVDAVP
S Lluch et al.
The Journal of pharmacology and experimental therapeutics, 228(3), 749-755 (1984-03-01)
The effects of vasopressin on the cerebral circulation were studied in conscious goats and in isolated human and goat cerebral arteries. Infusion of 1 to 12 mU of vasopressin into the internal maxillary artery of unanesthetized goats caused dose-dependent reductions
J F Liard et al.
Journal of cardiovascular pharmacology, 6(4), 713-719 (1984-07-01)
Two antagonists of the pressor action of arginine-vasopressin (AVP) were studied in conscious, normally hydrated dogs: 1-deaminopenicillamine-4-valine-8-D-arginine-vasopressin, or dPVDAVP, and 1-(beta-mercapto-beta, beta-cyclopentamethylene propionic acid)2-(O-methyl)tyrosine arginine-vasopressin, or d(CH2)5Tyr(Me)AVP. We first examined the hemodynamic effects of these antagonists when given alone. The
Paraventricular nucleus lesions attenuate the development of hypertension in DOCA/salt-treated rats.
T Nakata et al.
American journal of hypertension, 2(8), 625-630 (1989-08-01)
To determine whether paraventricular nucleus (PVN) can play a role in the hypertension in DOCA/salt-treated rats, DOCA/salt hypertension was produced in PVN lesions and sham-operated rats. In lesioned rats, the development of hypertension was significantly attenuated (day 7: 132 +/-
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