抗 VDAC/孔蛋白 兔抗

Voltage dependent anion channel 1 (VDAC1) is a highly regulated β-barrel membrane protein, encoded by the gene mapped to human chromosome 5q31.1. The encoded protein is a member of VDAC protein family and is mainly localized in the outer mitochondrial membrane.

synthetic peptide located at an internal putative cytoplasmic loop of human VDAC1/Porin (amino acids 152-169) conjugated to KLH. The sequence is identical in bovine and rabbit VDAC1, highly conserved in mouse and rat VDAC1 (single amino acid substitution), and has considerable homology (60-70%) with the human, rat, and mouse VDAC isoforms VDAC2 and VDAC3.

Anti-VDAC/porin antibody produced in rabbit has been used in western blotting.

Voltage dependent anion channel 1 (VDAC1) plays an essential role in several cellular processes. It helps in transport of ions and metabolites between the mitochondria and cytosol of the cell. Oligomerization of this protein facilitates discharge of cytochrome c to the cytoplasm, leading to apoptosis. VDAC1 expression is associated with the development of human papillomavirus (HPV)-related cervical cancer. Thus, VDAC1 knock down can be considered as a potent therapeutic strategy for treating HPV-induced cervical disease.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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