assay
≥95% (HPLC)
storage temp.
−20°C
SMILES string
CC(C)C(N)C(=O)NC(CC(O)=O)C(=O)NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O
Biochem/physiol Actions
Has natriuretic activity equivalent to Arg8-vasopressin with low pressor activity
Other Notes
Originally isolated from bovine posterior pituitary, thought to be a storage form of Arg8-vasopressin
H J Gitelman et al.
Science (New York, N.Y.), 207(4433), 893-896 (1980-02-22)
Extracts of fresh-frozen bovine neurohypophysis were purified by chromatographic techniques to isolate and characterize the components that produce natriuresis in nondiuretic dogs. Two compounds with natiuretic properties similar to those of synthetic arginine vasopressin accounted for most of the natriuretic