生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
效能
2-4 mg per mL effective concentration (determined by immunoblotting, using mouse brain and rat brain extracts)
分子量
antigen ~55 kDa
种属反应性
rat, mouse
包装
pkg of 200 μL
储存条件
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
浓度
~1.0 mg/mL
技术
microarray: suitable
western blot: 2-4 μg/mL using mouse brain and rat brain extracts (S1 fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC32A1(140679)
mouse ... Slc32a1(22348)
rat ... Slc32a1(83612)
一般描述
Vesicular GABA transporter (VGAT), also known as solute carrier family 32 member 1 (SLC32A1) or vesicular inhibitory amino acid transporter (VIAAT), is encoded by the gene localized on human chromosome 20q11.23. The encoded protein is highly expressed in both γ-aminobutyric acid -ergic (GABAergic) and glycinergic nerve endings.
免疫原
synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse VGAT. This sequence is identical in rat VGAT and highly conserved (single a.a. substitution) in human VGAT.
应用
Anti-Vesicular GABA Transporter antibody produced in rabbit has been used in:
- immunohistochemistry
- western blot
- immunocytochemistry
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
生化/生理作用
Vesicular GABA transporter (VGAT) plays a vital role in loading of presynaptic vesicles with glycine and γ-aminobutyric acid (GABA). VGAT is precisely involved in packing GABA into synaptic vesicles. In addition, it also has a crucial role in inhibitory synaptic transmission. Genetic variations in the gene leads to hyperekplexia.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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