V5764
Anti-Vesicular GABA Transporter antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-VGAT
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
potency
2-4 mg per mL effective concentration (determined by immunoblotting, using mouse brain and rat brain extracts)
mol wt
antigen ~55 kDa
species reactivity
rat, mouse
packaging
pkg of 200 μL
storage condition
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
concentration
~1.0 mg/mL
technique(s)
microarray: suitable, western blot: 2-4 μg/mL using mouse brain and rat brain extracts (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC32A1(140679)
mouse ... Slc32a1(22348)
rat ... Slc32a1(83612)
General description
Vesicular GABA transporter (VGAT), also known as solute carrier family 32 member 1 (SLC32A1) or vesicular inhibitory amino acid transporter (VIAAT), is encoded by the gene localized on human chromosome 20q11.23. The encoded protein is highly expressed in both γ-aminobutyric acid -ergic (GABAergic) and glycinergic nerve endings.
Immunogen
synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse VGAT. This sequence is identical in rat VGAT and highly conserved (single a.a. substitution) in human VGAT.
Application
Anti-Vesicular GABA Transporter antibody produced in rabbit has been used in:
- immunohistochemistry
- western blot
- immunocytochemistry
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Vesicular GABA transporter (VGAT) plays a vital role in loading of presynaptic vesicles with glycine and γ-aminobutyric acid (GABA). VGAT is precisely involved in packing GABA into synaptic vesicles. In addition, it also has a crucial role in inhibitory synaptic transmission. Genetic variations in the gene leads to hyperekplexia.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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法规信息
常规特殊物品
此项目有
Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats
Lin B
Cardiovascular Psychiatry and Neurology (2010)
Cyclin-Dependent Kinase 5 Is Involved in the Phosphorylation of Gephyrin and Clustering of GABAA Receptors at Inhibitory Synapses of Hippocampal Neurons
Kalbouneh H
PLoS ONE, 9 (2014)
Distribution and Posttranslational Modification of Synaptic ERα in the Adult Female Rat Hippocampus
Tabatadze N
Endocrinology, 154, 2013-2013 (2013)
Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
Tritsch NX
Nature, 490, 262-266 (2012)
A critical role for glycine transporters in hyperexcitability disorders
Harvey RJ
Frontiers in Molecular Neuroscience (2008)
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