Merck
CN

W4769

Sigma-Aldrich

Monoclonal Anti-WIPI-1 antibody produced in mouse

~1.5 mg/mL, clone WIPI1-4, purified immunoglobulin, buffered aqueous solution

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别名:
Anti-ATG18, Anti-WIPI-1α, Anti-WIPI49

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

antibody product type

primary antibodies

克隆

WIPI1-4, monoclonal

形式

buffered aqueous solution

分子量

antigen ~49 kDa

species reactivity

human, mouse, bovine, rat

浓度

~1.5 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extract of G361 cells

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... WIPI1(55062)
mouse ... Wipi1(52639)
rat ... Wipi1(303630)

一般描述

Monoclonal Anti-WIPI-1 (mouse IgG1 isotype) is derived from the hybridoma WIPI1-4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human WIPI-1, conjugated to KLH. WIPI-1 (WD repeat domain phosphoinositide-interacting protein 1) the mammalian orthologue of Atg18 in S. cerevisiae and A. thaliana, is a member of the WIPI subfamily of WD-repeat (Trp-Asp) proteins. WIPI-1 has a 7-bladed propeller structure and contains a conserved motif for interaction with phospholipids. WIPI-1 is expressed in normal human tissues with high levels in skeletal muscle, heart and testis.

应用

Monoclonal Anti-WIPI-1 antibody has been used in immunoblotting, immunoprecipitation.

生化/生理作用

WIPI-1 (WD repeat domain phosphoinositide-interacting protein 1) plays an important role in signal transduction, transcription regulation and apoptosis. Endogenous WIPI-1 partially colocalizes with the autophagosomal marker LC3 and induction of autophagy leads to the accumulation of WIPI-1 in large vesicular and cup-shaped structures that are characteristic for autophagy-linked proteins. WIPI-1 is aberrantly expressed in human cancer and is linked to starvation induced autophagy.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

法规信息

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Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy
Proikas-Cezanne T, et al.
Febs Letters, 581(18), 3396-3404 (2007)
WIPI-1alpha(WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
Proikas-Cezanne T, et al.
Oncogene, 23(58), 9314-9314 (2004)

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