WH0000650M2
Monoclonal Anti-BMP2 antibody produced in mouse
clone 1A11, purified immunoglobulin, buffered aqueous solution
别名:
Anti-BMP2A, Anti-Bone Morphogenetic Protein 2
一般描述
BMP2 (bone morphogenetic protein 2) is expressed in heart, lung and dorsal aorta. It is mapped to human chromosome 20p12.3.
免疫原
BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
生化/生理作用
BMP2 (bone morphogenetic protein 2) plays a vital role in the activation of the autonomic lineage-specific basic−helix-loop-helix protein, MASH1. It also plays a key role in autonomic neurogenesis in neural crest stem cells in vitro. In addition to its osteogenic activity, BMP2 also participates in cardiac morphogenesis. Mutation in the BMP2 gene is associated with osteoporosis.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Linkage of osteoporosis to chromosome 20p12 and association to BMP2
Styrkarsdottir U, et al.
PLoS Biology, 1(3), e69-e69 (2003)
BMP2 is required for early heart development during a distinct time period
Schlange, et al.
Mechanisms of Development, 91(1-2), 259-270 (2000)
Alternative neural crest cell fates are instructively promoted by TGF beta superfamily members
Shah NM, et al.
Cell, 85(3), 331-343 (1996)
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer
Tomlinson IPM, et al.
PLoS Genetics, 7(6), e1002105-e1002105 (2011)
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